Publication Date:
2021-03-26
Description:
Periodontitis is a common inflammatory disease characterized by a complex aetiology which is the result of a combination of genetic and environmental factors. Genetic variants linked to periodontitis disease were already investigated, however little was known regarding the severity of this disease. Recently long runs of homozygosity were associated with several multifactorial diseases. Therefore, in our work, we tried to assess the role of runs of homozygosity (ROH) and periodontitis status. We found an association between the excess of homozygosity due to ROH and staging of periodontitis. More in detail, the total amount of homozygosity due to ROH is positively associated with increased severity of periodontitis (p = 0.0001). Regression tree analysis showed the impact of ROH burden in discriminating individuals with mild periodontitis stages I-II and periodontitis stages III-IV (p 1). Among them, we found a total of 33 genes. Interestingly, some of these genes were previously associated with granulocyte or platelet measures, both linked to the onset and the progression of periodontal disease. Our results suggest the not only single variants association test could help to risk assessment but even individual genomic features; furthermore, our ROH mapping highlighted the possible role of multiple genes in periodontal development.
Print ISSN:
0964-6906
Electronic ISSN:
1460-2083
Topics:
Biology
,
Medicine
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