ISSN:
1573-8221
Keywords:
hypophyseal adenoma
;
growth hormone
;
prolactin
;
somatoliberin
;
somatostatin
;
cell cultures
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445426
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