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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 56 (1995), S. 177-180 
    ISSN: 1432-0827
    Keywords: Weight lifters ; Athletes ; Bone turnover ; Osteocalcin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Physical activity has been suggested to be one of the determinants of bone turnover and to prevent age-related bone loss. To examine this we measured the serum levels of osteocalcin (bone Gla-protein, BGP), C-terminal procollagen peptide (PICP), serum alkaline phosphatase, bone-specific alkaline phosphatase, and S-calcium as indices of bone formation in 19 actively performing and 15 ex-lifters. All were nationally or internationally ranked male athletes. Their values were compared with those from 38 age- and gendermatched controls. Actively performing weight lifters had 35% higher (P〈0.05) serum concentration of osteocalcin than the controls. The ex-lifters did not differ from the agematched controls. Also serum calcium was elevated in active lifters (6%) (P〈0.01) but not in ex-lifters. No difference was found for serum-ALP, B-ALP, or PICP in either of the groups. Our study indicates that in addition to an already documented and well-known higher bone mineral density in heavily exercising athletes, they have an indication of higher bone formation as measured by biochemical markers. In athletes who have retired from competitional training, however, the bone formation does not differ from that of more sedentary controls.
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  • 2
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical analysis (ICPES). Bone specimens from five femoral heads were used. The trabecular content of calcium (Ca) and phosphorus (P) was analyzed by the three different methods. The FDX method allows for a microstructural analysis of intact, methylmetacrylate-embedded, undecalcified bone and the measuring points can thus be distinctly identified centrally in each trabecula. The analysis yielded 25.8±0.7 wt% Ca and 10.5±0.1 wt % P, compared with 22.2±0.5 and 23.0±1.0 wt % Ca, and 9.83±0.21 and 10.02±0.44 wt % P for INAA and ICPES, respectively. The EDX analysis was calibrated by consecutive measurements of a hard, pressed tablet of hydroxyapatit of known content. The mean Ca content deviated with-0.38 wt % from the given content and P with-0.89 wt %. We could not verify any particular interference from the embedding procedure, however, it is possible that the relatively lower P content still may reflect this. The magnesium (Mg) concentration was 0.31±0.02 wt % by EDX and 0.26±0.02 wt % by INAA. The EDX analytical method provides a useful tool for simultaneous elemental quantification in bone. It has the advantage of permitting the use of cation bone biopsy material and thus allowing for a unique microstructural evaluation of the degree of mineralization. By comparison with other established methods, the assessment of accuracy and reliability indicates that the measurements are well in range for the major constituents, Ca and P, whereas INAA is more sensitive in determining trace elements.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 59 (1996), S. 245-248 
    ISSN: 1432-0827
    Keywords: Key words: Athletes — Bone mineral density — Dual energy x-ray absorptiometry — Ex-athletes — Physical activity — Unloaded — Weight-loaded.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bone mineral density (BMD) was measured in the upper part of the skull, the femoral neck, and the total body by dual energy X-ray absorptiometry in 56 male and 33 female active athletes, 18–40 years of age, together with 64 male ex-weight lifters, 35–79 years of age. The active athletes were compared with 41 male and 54 female controls, the ex-weight lifters with 133 male controls. The purpose of the study was to see if BMD in the upper part of the skull, a region virtually unaffected by physical load, is different in athletes and controls. The male athletes had a 3% higher BMD for the total body and 12% for the hip, whereas the BMD for the upper part of the skull was 10% lower than controls. Corresponding BMD values for the female athletes were 4% higher for total body and 10% for the femoral neck, and the upper part of the skull was 7% lower than in controls. After 65 years of age there was no difference in BMD comparing ex-weightlifters and controls. Using a constructed ratio BMD total body to BMD upper part of the skull, the ex-weight lifters had 10% higher values also after age 65. It appears that bone mass is higher in weight-loaded areas and lower in an unloaded region, such as the upper part of the skull, in exercising athletes. After cessation of the active career, the bone mass approaches that of the controls and after 65 years of age, no difference was found comparing ex-weight lifters and controls. Due to the apparent bone mass shift from unloaded skeletal regions to loaded skeletal regions that seems to take place in active athletes, the constructed ratio, BMD total body to BMD upper part of the skull, seems to discriminate the influence on the skeleton in a more sensitive way than measuring the BMD in defined skeletal regions on their own. By using this constructed ratio, the influence on bone mass of physical exercise early in life is also detectable at older ages.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 57 (1995), S. 325-328 
    ISSN: 1432-0827
    Keywords: Bone mineral density ; Bone mass measurements ; Duarenergy X-ray absorptiometry ; Weight lifting ; physical activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract This cross-sectional study was done in order to ascertain whether there is a lifelong beneficial effect on bone mineral density (BMD) of early, long-lasting, and intense physical exercise. Forty-eight male ex-weight lifters, mean age 64 years (range 50–79) participated. They had followed a training program of an average of 10 hours/week (range 4–20) for an average of 13 years (range 1–34). They had all retired from competitive sport an average of 30 years (range 7–50) ago. Sixty-six age-matched volunteers served as controls. The bone mineral density (BMD, areal density, g/cm2) in the total body, spine, and hips and the fat content and lean body mass were measured with the LUNAR DPX bone mass scanner. In ex-weight lifters 50–64 years of age, the BMD was greater than in controls. After 65 years, no difference was found between the former weight lifters and their controls.
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  • 5
    ISSN: 1432-0827
    Keywords: Key words: Bone mineral density — Dual energy X-ray absorptiometry — Lean body mass — Fat — Normative data.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bone mineral density (BMD) and soft tissue composition were measured by dual energy X-ray absorptiometry (DXA) 3–4 years apart in 273 men and women aged 23–90. We found different rates of BMD loss in different skeletal regions. There were also different rates of BMD loss in different regions within the hip. Average rates of loss for male subjects 50 years of age and above for BMD total body were 0.1%/year and for femoral neck 1.5%/year, whereas lumbar spine (L2–L4) increased by 0.4%/year. Average rates of loss for female subjects 50 years of age and above for BMD total body were 0.0%/year, femoral neck 0.9%/year, and lumbar spine (L2–L4) 0.1%/year.
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  • 6
    ISSN: 1432-0827
    Keywords: Key words: Ovariectomy — Low calcium diet — Clodronate — Bone volume — Bone strength.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The aim of this study was to evaluate the contribution of a low calcium diet to the cortical and trabecular osteoporosis seen in ovariectomized rats after 7 weeks on a low calcium diet and to investigate the effects of the bisphosphonate clodronate on this development of osteoporosis. Thirty-six mature, female Wistar rats were randomized into four groups: Ovx−B (bisphosphonate) and Ovx−C (control) were ovariectomized, and Sham−Ca (low calcium) and Sham+Ca (normal calcium) were sham operated. The first three groups were fed a low calcium diet (0.01%) and Sham+Ca normal rat chow (Ca 1.1%). The Ovx−B received 10 mg/kg s.c. clodronate daily for nine weeks, and Ovx−C, Sham−Ca, and Sham+Ca received the same volumes of saline. Bone mineral turnover measured as 85Sr-uptake was increased in all low calcium groups compared to Sham+Ca. The Sham+Ca femora had higher dry weight and ash weight than the other groups, and Ovx−C had higher dry weight compared with Ovx−B and Sham−Ca. Calcium content was lower in both Ovx groups compared to both Sham groups. Magnesium was lower in all groups compared to Sham+Ca and higher in Ovx−B compared with Ovx−C. In the femoral shaft, Sham+Ca had significantly higher ultimate bending moment, energy absorption, and deflection compared to the other three groups. Ultimate bending moment was higher in Sham−Ca than in Ovx−C. Stiffness was increased in both Sham+Ca and Ovx−B compared to Ovx−C. The maximum stress in the femoral midshaft was higher in Sham+Ca than in the other groups, and higher in Ovx−B than in Ovx−C. Histomorphometry showed increased medullary area in all low calcium groups compared to Sham+Ca and larger cortical area in Sham+Ca and Ovx−B compared to Ovx−C. Compared to Sham+Ca the trabecular bone volume was decreased to 30% in Sham−Ca and to 9% in Ovx−C, but was unchanged in Ovx−B. The low calcium diet generally increased bone mineral turnover and reduced the tibial bone volume. Femoral changes led to a reduction of cortical fracture strength and maximal stress. Ovariectomy in addition to a low calcium diet reduced femoral strength even more. Daily injections of clodronate to ovariectomized rats on a low calcium diet increased femoral shaft stiffness and maximum stress, and clodronate preserved both trabecular and cortical tibial bone volume completely.
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