Publication Date:
1996-05-17
Description:
Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. However, the molecular basis for this elevation is not known. The partially dissociated hippocampal ("zipper") slice preparation was used to analyze single Ca2+ channel activity in CA1 neurons of adult and aged rats. Total L-type Ca2+ channel activity in patches was found to increase with aging, primarily because of an increase in the density of functional channels. Learning in aged animals was inversely correlated with channel density. This increase in functional Ca2+ channels with aging could underlie the vulnerability of neurons to age-associated neurodegenerative conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thibault, O -- Landfield, P W -- AG04542/AG/NIA NIH HHS/ -- AG10836/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1996 May 17;272(5264):1017-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, College of Medicine, University of Kentucky, Lexington 40536-0084, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638124" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/*metabolism
;
Animals
;
Calcium/*metabolism
;
Calcium Channels/*metabolism
;
Hippocampus/*cytology/*metabolism
;
In Vitro Techniques
;
Male
;
Maze Learning
;
Membrane Potentials
;
Patch-Clamp Techniques
;
Pyramidal Cells/*metabolism
;
Rats
;
Rats, Inbred F344
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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