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Effect of hydroxyapatite coating on bone growth into porous titanium alloy implants under loaded conditions (1994)

Oonishi, Hironobu ; Noda, Tomohiro ; Ito, Seiichi ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Biomaterials 5 (1994), S. 23-37

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ISSN: 1045-4861

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Titanium alloy tibial segmented defect repair devices whose stems were coated with two layers of titanium alloy beads (Ti-6A1-4V, bead diameter c. 750 μm) were implanted in six beagle dogs. In four of the animals stems had been plasma-sprayed with hydroxyapatite (HA); the other two animals received devices with uncoated stems. Devices intended for 6-month and 3-month evaluation were implanted in right and left tibiae, respectively. Because the amount of bone ingrowth into pore spaces was greater in cortical bone than in cancellous bone, stems were more stable and firmer in the cortical bone. In stems coated with HA, new bone tissue came into contact with the surface of beads in the superficial layer of the stem faster than in stems not so coated. Furthermore, new bone tissue entered into pore spaces in these stems earlier, in larger amounts, and reached more deeply, binding directly to the beads. Rate and quality of bone ingrowth did not differ between the 3-month and 6-month tibiae; in other words, optimal bone ingrowth was attained within 3 months postimplantation. © 1994 John Wiley & Sons, Inc.

Additional Material: 7 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jab.770050105

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Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs (1998)

Noda, Tomohiro ; Watanabe, Tomoyuki ; Kohda, Akira ; [et al.]

Springer

Investigational new drugs 16 (1998), S. 121-128

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ISSN: 1573-0646

Keywords: cardiotoxicity ; anthracycline ; doxorubicin ; SM-5887 ; dog

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Abstract This study was designed to investigate the chronic cardiotoxic potential of SM-5887 and a possible deteriorating effect of SM-5887 on low-grade cardiotoxicity pre-induced by doxorubicin in beagle dogs. In the chronic treatment, beagle dogs of each sex were given intravenously once every 3 weeks, either a sublethal dose of doxorubicin (1.5 mg/kg) or SM-5887 (2.5 mg/kg). The experiment was terminated 3 weeks after the ninth dosing. Animals which received over six courses of doxorubicin demonstrated the electrocardiogram (ECG) changes, decrease of blood pressure and high-grade histopathological cardiomyopathy, while animals which were terminally sacrificed after the SM-5887 administration did not show any changes in ECG, blood pressure and histopathological examinations. To examine a possibly deteriorating cardiotoxic effect of SM-5887, low-grade cardiomyopathy was induced in dogs by four courses of doxorubicin (1.5 mg/kg). Nine weeks after pre-treatment, dogs were given four courses of either doxorubicin (1.5 mg/kg) or SM-5887 (2.5 mg/kg) once every 3 weeks. The low-grade cardiotoxic changes were enhanced by the additional doxorubicin treatment. On the contrary, the SM-5887 treatment did not progress the grade of cardiomyopathy. In conclusion, SM-5887 does not have any potential of chronic cardiotoxicity and deteriorating effect on doxorubicin-induced cardiotoxicity in dogs.