ISSN:
1573-6830
Keywords:
GnRH
;
GnRH receptor
;
calcium
;
protein kinase C (PKC)
;
arachidonic acid
;
luteinizing hormone (LH)
;
follicle stimulating hormone (FSH)
;
inositol phosphates
;
G-proteins
;
IP3
;
diacyl-glycerol, leukotrienes
;
MAP kinase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq). 2. Theα subunit of Gq triggers enhanced phosphoinositide turnover and the elevation of multiple second messengers required for gonadotropin release and biosynthesis. 3. The messenger molecules IP3, diacylglycerol, Ca2+, protein kinase C, arachidonic acid and leukotriene C4 cross-talk in a complex networks of signaling, culminating in gonadotropin release and gene expression.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02071315
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