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  • 1
    Description / Table of Contents: Measuring and Monitoring POPs: A Critique / R. S. S. Wu, A. K. Y. Chan, B. Richardson, D. W. T. Au, J. K. H. Fong, P. K. S. Lam and J. P. Giesy / pp. 1-6 --- Fish Models in Impact Assessment of Carcinogenic Potential of Environmental Chemical Pollutants: An Appraisal of Hermaphroditic Mangrove Killifish Kryptolebias marmoratus / S. Raisuddin and J.-S. Lee / pp. 7-15 --- Research on Ecotoxicology and Applications in Singapore: Description of the Sponge Aggregation Assay / B. Goh / pp. 17-29 --- Perspective of Ecotoxicological Conduction for Water Quality Monitoring in Thailand / N. Tapaneeyakul / pp. 31-35 --- Chronic Effects of Waterborne PFOS Exposure on Growth, Development, Reproduction and Hepatotoxicity in Zebrafish / Y. Du, X. Shi, K. Yu, C. Liu and B. Zhou / pp. 37-54 --- Testicular Toxicity of Arsenic on Spermatogenesis in Fish / F. T. Celino, S. Yamaguchi, C. Miura and T. Miura / pp. 55-60 --- Prostanoid Signaling Mediates Circulation Failure Caused by TCDD in Developing Zebrafish / H. Teraoka, A. Kubota, Y. Kawai and T. Hiraga / pp. 61-80 --- Molecular Basis for Differential Dioxin Sensitivity in Birds: Characterization of Avian AHR Isoforms / E.-Y. Kim, H. Iwata, T. Yasui, N. Inoue, J.-S. Lee, D. G. Franks, S. I. Karchner, M. E. Hahn and S. Tanabe / pp. 81-86 --- Application of Bioassays for the Detection of Dioxins and Dioxin-like Compounds in Wastes and the Environment / H. Takigami, G. Suzuki and S. Sakai / pp. 87-94 --- Modulation of Expression of Oxidative Stress Genes of the Intertidal Copepod Tigriopus japonicus after Exposure to Environmental Chemicals / J.-S. Lee and S. Raisuddin / pp. 95-105 --- Application of Ascidian DNA Microarray Analysis for Risk Assessment of Marine Chemical Pollutants / K. Azumi, S. Amano, S. V. Sabau, A. Kamimura, N. Satoh and R. Koyanagi / pp. 107-110 --- Immune Gene Expression Levels Correlate with the Phenotype of Japanese Flounder Exposed to Heavy Oil / J.-Y. Song, K. Nakayama, Y. Murakami and S.-I. Kitamura / pp. 111-122 --- Yeast OMICS System for Environmental Toxicology / Y. Tanaka, T. Higashi, R. Rakwal, J. Shibato, S. Wakida and H. Iwahashi / pp. 123-132 --- Genomic Response in Daphnia to Chemical Pollutants / H. Watanabe, K. Kobayashi, Y. Kato, S. Oda, R. Abe, N. Tatarazako and T. Iguchi / pp. 133-142 --- Medaka DNA Microarray: A Tool for Evaluating Physiological Impacts of Various Toxicants / K. Kishi, E. Kitagawa, H. Iwahashi, K. Suzuki and Y. Hayashi / pp. 143-154 --- Sensing of Heavy Metals Using Caenorhabditis elegans DNA Microarray / N. Tominaga, T. Matsuno, S. Kohra and K. Arizono / pp. 155-161 --- Application of Microarray Technology to Toxicity Evaluation in Wild Common Cormorants Contaminated with Persistent Organic Pollutants / K. Nakayama, H. Iwata, L. Tao, K. Kannan, M. Imoto, E.-Y. Kim, K. Tashiro and S. Tanabe / pp. 163-170 --- Effects of Heavy Oil on the Developing Japanese Flounder Paralichthys Olivaceus / H. Nokame, S.-I. Kitamura, K. Nakayama, S. Matsuoka, H. Sakaguchi and Y. Murakami / pp. 171-178 --- Genetic Polymorphisms Influencing Arsenic Metabolism in Human: Evidence from Vietnam / T. Agusa, J. Fujihara, T. B. Minh, P. T. K. Trang, H. Takeshita, H. Iwata, P. H. Viet and S. Tanabe / pp. 179-185 --- Low Induction Potencies of Cytochrome P450 2B and 3A by Persistent Organic Pollutants in Baikal Seal (Pusa sibirica) / H. Sakai, H. Iwata, E.-Y. Kim, E. A. Petrov and S. Tanabe / pp. 187-195 --- Effects of Dioxins and Related Compounds in the Liver of Wild Baikal Seals: An Implication from a Toxicogenomic Approach / S. Hirakawa, D. Imaeda, K. Nakayama, E.-Y. Kim, T. Kunisue, S. Tanabe, E. A. Petrov, V. B. Batoev and H. Iwata / pp. 197-205 --- Interspecies Difference in Susceptibility of TCDD-induced Avian CYP1A5 Transactivation is Dependent on AHR1, not on CYP1A5 Promoter/Enhancer Region / J.-S. Lee, E.-Y. Kim, H. Iwata and S. Tanabe / pp. 207-224 --- Molecular Characterization of Avian Metallothionein (MT) 1 and 2 Isoforms: mRNA Expression, Transactivation Potency, and Detoxification Potential Associated with Element Exposure / D.-H. Nam, E.-Y. Kim and H. Iwata / pp. 225-239 --- Vacuolar-type H+-Translocating ATPase is the Target of Tributyltin Chloride / K. Akiyama, S. Chardwiriyapreecha, T. Chahomchuen, N. Sugimito, T. Sekito, S. Nishimoto, T. Sugahara and Y. Kakinuma / pp. 241-249 --- Characterization of the Vacuolar Transporters for Amino Acid Recycling in Yeast Autophagy / T. Chahomchuen, T. Sekito, K. Hondo, S. Nishimoto, T. Sugahara and Y. Kakinuma / pp. 251-261 --- The Structure-Activity Relationships of Flaxseed Lignan, Secoisolariciresinol / T. Sugahara, S. Yamauchi, S. Nishimoto, A. Kondo, F. Ohno, S. Tominaga, Y. Nakashima, T. Kishida, K. Akiyama, M. Maruyama and Y. Kakinuma / pp. 263-268 --- Risk Assessment of Heavy Oil on Terrestrial Mammals / S. Nishimoto, M. Yamawaki, S.-I. Kitamura, K. Akiyama, Y. Kakinuma and T. Sugahara / pp. 269-274 --- The Role of the Earthworm, Pheretima (Metaphire) hilgendorfi, in Terrestrial Ecosystem Nutrient Cycling / M. Nozaki, C. Miura, Y. Tozawa and T. Miura / pp. 275-279 --- Toxicological Effects of Heavy Oil on Carp by NMR-based Metabolic Profiling of Plasma / S. Uno, E. Kokushi and J. Koyama / pp. 281-289 --- In vitro and in vivo Estrogenic Effects of Fluorotelomer Alcohols in Medaka (Oryzias latipes) / H. Ishibashi, R. Yamauchi, M. Matsuoka, J.-W. Kim, M. Hirano, A. Yamaguchi, N. Tominaga and K. Arizono / pp. 291-301 --- Expression Analysis of Ecdysone Receptor and Ultraspiracle through Molting Period in Mysid Crustacean, Americamysis bahia / M. Hirano, H. Ishibashi, R. Yamauchi, J.-W. Kim and K. Arizono / pp. 303-310 --- Temporal Variation of PCDDs, PCDFs and PCBs in Baikal Seals (Pusa sibirica) / D. Imaeda, T. Kunisue, Y. Ochi, H. Iwata, O. Tsydenova, S. Takahashi, M. Amano, E. A. Petrov, V. B. Batoev and S. Tanabe / pp. 311-320 --- Hydroxylated Polychlorinated Biphenyls in the Blood of Cetacean Species Stranded along the Japanese Coast / S. Murata, T. Kunisue, S. Takahashi, T. K. Yamada and S. Tanabe / pp. 321-330 --- Polybrominated Diphenyl Ethers and Hexabromocyclododecanes in Japanese Human Adipose Tissues / T. Isobe, H. Oda, N. Takayanagi, T. Kunisue, M. Nose, T. Yamada, H. Komori, N. Arita, N. Ueda, S. Takahashi and S. Tanabe / pp. 331-338 --- Spatial Distribution and Accumulation of Organohalogen Compounds in Human Breast Milk from the Philippines / G. Malarvannan, T. Kunisue, T. Isobe, A. Sudaryanto, S. Takahashi, M. Prudente and S. Tanabe / pp. 339-347 --- Cell-to-cell Contact is Required for Transfer of Tetracycline Resistance Gene tet(M) in Marine Bacteria / F. A. Neela, N. Nagahama and S. Suzuki / pp. 349-353 --- Occurrence Rates of Sulfamethoxazole and Erythromycin-Resistant Bacteria and Drug Concentrations in Wastewater of Integrated Aquaculture-Agriculture (VAC) Sites in Northern Vietnam / P. T. P. Hoa, S. Managaki, N. Nakada, H. Takada, D. H. Anh, P. H. Viet and S. Suzuki / pp. 355-359 --- Comparative Study of Pesticide Effects (Herbicide and Fungicide) on Zooplankton Community / K.-H. Chang, M. Sakamoto, J.-Y. Ha, T. Murakami, Y. Miyabara, S. Nakano, H. Imai, H. Doi and T. Hanazato / pp. 361-366 --- Succession of Harmful Algae Microcystis (Cyanophyceae) Species in a Eutrophic Pond / H. Imai, K.-H. Chang, M. Kusaba and S. Nakano / pp. 367-372
    Pages: Online-Ressource (X, 372 Seiten)
    ISBN: 9784887041455
    Language: English
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ZAP-70-deficient mice were generated by deleting the entire gene segment encoding ZAP-70 protein (Fig. la). ZAP-70 protein could not be detected in thymocytes from ZAP-70"7" mice by western blot analysis2 (data not shown). ZAP-70"7" mice appeared healthy and fertile under specific ...
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Phosphorylation of IκB by the IκB kinase (IKK) complex is a critical step leading to IκB degradation and activation of transcription factor NF-κB. The IKK complex contains two catalytic subunits, IKKα and IKKβ, the latter being indispensable for ...
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  • 4
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have determined the nucleotide sequence of Q8/9 d gene of the BALB/c strain of mice, isolated from Steinmetz's cosmid library. As for all other class I genes of the Qa region, the Q8/9 d gene spans approximately 4.7 kilobases (kb) and consists of seven exons and six introns. A seven bases deletion in exon 3 results in the occurrence of an early termination codon. Thus the Q8/9 d gene cannot encode a normal class I protein. Comparison of the nucleotide sequence of the Q8/9 d gene with that of other class I MHC genes revealed a stronger homology to Q7 and Q8 than to K, D, L, TL, and other Q genes. However, the gene cannot originate from a mere fusion between Q8 and Q9 genes except if the ancestor to putative Q8 d was markedly different from the present Q8 b gene. Using polymerase chain reaction (PCR) technology, we have confirmed the presence of a Q8/9 gene, identical to that present in cosmid 46.1, in the genome of BALB/cJ (Qa-2low). Finally, it has been reported that cDNA clone 94-A, which codes for a Qa-2 antigen, could derive from a transcript of gene Q8/9 d. The nucleotide sequences of gene Q8/9 d and of cDNA clone 94-A are distinctly different in their 5′ regions, in spite of an almost perfect matching in their 3′ regions. Thus, clone 94-A cannot derive from an mRNA transcribed from the Q8/9 d gene.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2012-07-21
    Print ISSN: 0944-1344
    Electronic ISSN: 1614-7499
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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  • 8
  • 9
    Publication Date: 2020-04-10
    Description: Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated with depression. Transcriptome analysis identified 3,306 differentially expressed transcripts, including inflammatory markers, melanopsins, and circadian clock genes. Further analyses revealed seasonal changes in multiple signaling pathways implicated in depression, including the nuclear factor erythroid-derived 2-like 2 (NRF2) antioxidant pathway. A broad-spectrum chemical screen revealed that celastrol (a traditional Chinese medicine) uniquely reversed winter behavior. NRF2 is a celastrol target expressed in the habenula (HB), known to play a critical role in the pathophysiology of depression. Another NRF2 chemical activator phenocopied these effects, and an NRF2 mutant showed decreased sociability. Our study provides important insights into winter depression and offers potential therapeutic targets involving NRF2.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2015-07-16
    Description: We report the first measurements of the complex refractive index (RI) at 375, 405, 532, and 781 nm for secondary organic aerosol (SOA) generated from isoprene/NO x photooxidation. At all wavelengths studied, slightly greater real components of the RI were observed for the SOA generated in the presence of SO 2 compared with those generated in its absence. Considering the chemical properties, the differences in the oxidation state and/or ratio of particle density to molecular weight of compounds in the SOA are considered to be the main factors determining the real components. The imaginary components at ≤532 nm were found to increase with increasing initial SO 2 concentration. The highly conjugated oligomers are suggested to be plausible chromophore candidates. This study suggests that when large amounts of SOA are generated after mixing of isoprene with NO x and SO x , light absorption of these SOA may compete with that of black carbon, especially at ultraviolet wavelengths.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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