Publication Date:
2011-03-09
Description:
We appreciate the comments of Seth et al. (1), because they provide an important finding that is supplementary to our paper (2). They show that recipient mice deficient in CD155 (Cd155−/− mice), a ligand for DNAM-1 (DNAX accessory molecule-1, CD226), exhibited shorter rather than longer survival than WT mice after bone marrow transplantation (BMT) with full MHC disparity. They also show that donor CD4+, but not CD8+, T cells were responsible for the poor survival of the recipient Cd155−/− mice, suggesting that the interaction of CD155 on recipient organs with the receptor ligand on donor CD4+ T cells protects recipient...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
Permalink