ISSN:
1476-5535
Keywords:
Pyrimidine biosynthesis
;
Fluorouracil resistance
;
Efrotomycin
;
Nocardia lactamdurans
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Nocardia lactamdurans, which produces the antibiotics efrotomycin and cephamycin C, exhibits essentially unregulated pyrimidine synthesis. Neither the first nor the second step is subject to feedback regulation. In a series of strains, comprising the original soil isolate, a set of spontaneous fluorouracil-resistant (FUR) mutants and the first improved efrotomycin producer, three of the pyrimidine biosynthetic enzymes were found to be coordinately regulated over a tenfold range. This amplification of enzyme activity accounts for the pyrimidine-related properties but not, at present, for their improved efrotomycin capacity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01578207
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