Publication Date:
2007-05-05
Description:
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ren, Ming -- Yoshimura, Yumiko -- Takada, Naoki -- Horibe, Shoko -- Komatsu, Yukio -- New York, N.Y. -- Science. 2007 May 4;316(5825):758-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17478724" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Axons/metabolism
;
Electric Stimulation
;
Excitatory Postsynaptic Potentials
;
Glutamic Acid/metabolism/pharmacology
;
*Inhibitory Postsynaptic Potentials
;
Interneurons/physiology
;
Mice
;
Mice, Inbred C57BL
;
Neural Inhibition
;
Patch-Clamp Techniques
;
Presynaptic Terminals/physiology
;
Pyramidal Cells/*physiology
;
Receptors, AMPA/physiology
;
Receptors, Kainic Acid/physiology
;
Synapses/*physiology
;
Synaptic Transmission
;
Visual Cortex/cytology/*physiology
;
gamma-Aminobutyric Acid/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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