Publication Date:
1985-02-15
Description:
The family of tyrosine-specific protein kinases includes proteins encoded by retroviral oncogenes as well as receptors for insulin and several growth factors. Antibodies to pp60src, the protein encoded by the src oncogene of Rous sarcoma virus (RSV), can specifically immunoprecipitate affinity-labeled insulin receptors from cultured human lymphocytes (IM-9 cells). This precipitation is specifically inhibited by the src gene product purified from RSV-transformed rat cells. These observations provide evidence that there is structural homology between the insulin receptors and pp60src.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perrotti, N -- Taylor, S I -- Richert, N D -- Rapp, U R -- Pastan, I H -- Roth, J -- New York, N.Y. -- Science. 1985 Feb 15;227(4688):761-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3918346" target="_blank"〉PubMed〈/a〉
Keywords:
Cross Reactions
;
Humans
;
Molecular Weight
;
Oncogene Protein pp60(v-src)
;
*Oncogenes
;
Protein Kinases/*immunology
;
Protein-Tyrosine Kinases
;
Receptor, Insulin/*immunology
;
Viral Proteins/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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