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  • 1
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    Combined functional genomic maps of the C. elegans DNA damage response (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-05
    Description: Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boulton, Simon J -- Gartner, Anton -- Reboul, Jerome -- Vaglio, Philippe -- Dyson, Nick -- Hill, David E -- Vidal, Marc -- 5R01HG01715-02/HG/NHGRI NIH HHS/ -- 7 R33 CA81658-02/CA/NCI NIH HHS/ -- P01CA80111-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):127-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778048" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Base Sequence ; Caenorhabditis elegans/*genetics/metabolism/physiology ; Caenorhabditis elegans Proteins/genetics/*physiology ; *Chromosome Mapping ; Computational Biology ; DNA Damage/*genetics ; DNA Repair/*genetics ; DNA Replication ; Gamma Rays ; Gene Silencing ; *Genes, Helminth ; Genome ; Humans ; Open Reading Frames ; Phenotype ; Proteome ; Proto-Oncogene Proteins/genetics ; Recombination, Genetic ; Transcription Factors ; Two-Hybrid System Techniques
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-17
    Description: Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the RB1 gene product, p105-RB, has been shown to form stable protein/protein complexes with the oncoproteins of two DNA tumor viruses, the adenovirus E1A proteins and the simian virus 40 (SV40) large T antigen. Neither of these viruses is thought to be associated with human cancer, but they can cause tumors in rodents. Binding between the RB anti-oncoprotein and the adenovirus or SV40 oncoprotein can be recapitulated in vitro with coimmunoprecipitation mixing assays. These assays have been used to demonstrate that the E7 oncoprotein of the human papilloma virus type-16 can form similar complexes with p105-RB. Human papilloma virus-16 is found associated with approximately 50 percent of cervical carcinomas. These results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dyson, N -- Howley, P M -- Munger, K -- Harlow, E -- CA13106/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Feb 17;243(4893):934-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, NY 11724.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2537532" target="_blank"〉PubMed〈/a〉
    Keywords: Adenovirus Early Proteins ; Amino Acid Sequence ; Antigens, Polyomavirus Transforming/genetics ; Cell Line ; DNA-Binding Proteins/genetics ; Eye Neoplasms/*genetics ; Humans ; Molecular Sequence Data ; Oncogene Proteins, Viral/*genetics/metabolism ; Papillomaviridae/*genetics ; Phosphoproteins/*metabolism ; Protein Binding ; Protein Biosynthesis ; Retinoblastoma/*genetics ; Retinoblastoma Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Functional antibody selection in ES cells [Applied Biological Sciences] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-10-30
    Description: Antibodies that modulate receptor function have great untapped potential in the control of stem cell differentiation. In contrast to many natural ligands, antibodies are stable, exquisitely specific, and are unaffected by the regulatory mechanisms that act on natural ligands. Here we describe an innovative system for identifying such antibodies by...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
    Electronic Resource
    Electronic Resource
    New Phases in the System Al 2 O 3 –SO 3 –H 2 O at Temperatures above 100° C (1965)
    [s.l.] : Nature Publishing Group
    Nature 205 (1965), S. 358-359 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SOLUTIONS of aluminium sulphate (especially 'basic' solutions, in which the molar ratio SO3: Al2O8 is less than 3) hydrolyso readily at elevated temperatures1 to produce in most instances the compound 3Al2O3. 4SO3.-9H2O (phase B, Table 1). A further survey of the ternary system has now been made ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/205358a0
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  • 5
    Electronic Resource
    Electronic Resource
    Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
    Amsterdam : Elsevier
    Trends in Cell Biology 1 (1991), S. 114 
    Details
    ISSN: 0962-8924
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0962-8924(91)90106-J
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  • 6
    Electronic Resource
    Electronic Resource
    Chromatographic integration methods - The Royal Society of Chemistry, Cambridge, 1990 (ISBN 0-85186-587-9). xiv + 160 pp. Price £ 35.00
    Amsterdam : Elsevier
    Analytica Chimica Acta 249 (1991), S. 564 
    Details
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)83036-6
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  • 7
    Electronic Resource
    Electronic Resource
    Similarity of nucleotide sequences at splicing sites (1988)
    [s.l.] : Nature Publishing Group
    Nature 333 (1988), S. 402-402 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - We report an intriguing similarity between a sequence involved in process-ing of mitochondrial RNA and the con-sensus sequence at the 5 '-splice site of introns in transcripts of nuclear genes. In Aspergillus nidulans, synthesis of mature mitochondrial RNA occurs by cleavage and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/333402a0
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  • 8
    Electronic Resource
    Electronic Resource
    (d, p) Reactions and the combination of PIXE-PIGME techniques for the analysis of biomass samples (1989)
    Springer
    Journal of radioanalytical and nuclear chemistry 129 (1989), S. 163-170 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract To control environmental pollution, a biodegradation technique involving a biomass is used to degrade the liquid wastes from certain industrial processes before disposal. (d, p) reactions were used to study the degradation process and the extent of removal of carbon and nitrogen. The PIXE-PIGME technique was used for the simultaneous study of the compositions of the biomass, the feed and the treated material. Measurements were obtained using protons of 2.5 MeV (for the PIXE-PIGME measurements) and deuterons of 2.0 MeV using currents of the order of 25nA. The X-ray and γ-ray data were recorded simultaneously. Absolute concentrations were obtained by comparison with measurements of calibration standards. Results show that 54–58% of the carbon and 45–50% of the nitrogen is removed from the wastes and that the biomass is concentrating Cl, Ti, Ni and Fe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02037579
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  • 9
    Electronic Resource
    Electronic Resource
    The stopping-power correction in proton-induced x-ray emission analysis (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 13 (1984), S. 100-102 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The thick-target yield of characteristic x-rays from a series of gold-silver binary alloys has been determined experimentally (relative to the yield from the pure elements) under proton bombardment, using proton energies of 1. 5, 2. 0 and 2. 5 MeV. The yield per unit concentration of gold or silver varies with alloy composition because of the progressively varying effects of proton stopping power (specific energy loss) and x-ray self-absorption in the target materials. Theoretical yields have been calculated using tabulated data for stopping power and x-ray absorption. When both of these effects are taken into account, agreement with experiment is satisfactory. These results can be made the basis of stopping power and self-absorption corrections in proton-induced x-ray emission analysis.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300130303
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  • 10
    Electronic Resource
    Electronic Resource
    The self-absorption correction in PIXE microanalysis (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 15 (1986), S. 201-205 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The self-absorption effect for characteristic x-rays produced by proton bombardment of thick targets has been studied experimentally by the ‘tracer-layer’ and ‘angular distribution’ techniques. Four proton energies have been used. The experimental data have been converted into f(χ) curves which can be used to apply a self-absorption correction in PIXE microanalysis.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300150310
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