ISSN:
1420-9071
Keywords:
Monoaminoguanidine
;
alloxan diabetes
;
nephropathy
;
sorbitol
;
nonenzymatic protein glycosylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Monoaminoguanidine administration (25 mg/kg b.wt, i.p. for 14 weeks) to alloxan diabetic rats (blood glucose ≥250 mg/dl) decreased the nonenzymatic protein glycosylation and sorbitol levels. It prevented development of Armanni-Ebstein tubular lesions, pathological changes in the glomerular capillary tufts and glomerular basement membrane thickening in the kidney.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01958151
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