Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Molecular microbiology
1 (1987), S. 0
ISSN:
1365-2958
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
The replication of euckaryotic DNA is normally initiated at each origin only once per ceil cycle. Yet, In spite of this restriction, the 2μ plasmid of yeast has evolved an elegant mechanism which can allow it to rapidly amplify its copy number without initiating multiple rounds of replication. It achieves this by exploiting a plasmid-en coded site-specific recombination system in a way that is apparently unique to this plasmid. The 2μ plasmid has also evolved a mechanism that allows effective partition of itself between mother and daughter cells. Together these processes ensure the persistence of the 2μ plasmid within a population, even though retention of the plasmid Is of no advantage to the host cell and causes a slightly slower growth rate. The success of this survival strategy is illustrated by the near ubiquity of the 2μ. plasmid in both wild-type and laboratory strains of yeast.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2958.1987.tb00519.x
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