ISSN:
1573-8744
Keywords:
drug delivery system
;
anticancer agent
;
water-in-oil emulsion, gelatincontaining water-in-oil emulsion
;
intramuscular injection
;
lymph nodes
;
enhanced delivery into the lymphatic system
;
sustained release
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Further work was undertaken to clarify the mechanism of enhanced delivery of anticancer agents into rat lymph nodes by water-in-oil (W/O) emulsions. Radiolabeled [ 131 I] iodohippuric acid (IH, watersoluble model compound) and [ 14 C]tripalmitin (TP, tracer of oil) were administered intramuscularly, and radioactive concentrations in blood, lymph nodes, and muscles were determined. Also, a new type of emulsion, gelatin-containing W/O (W/O-G) emulsion, was manufactured to be used as a delivery system for the anticancer agents. It was found that the rate of transfer of TP into lymph nodes was enhanced in the following order: oil, oil-in-water (O/W) emulsion, W/O emulsion, and W/O-G emulsion. The transfer of IH into lymph nodes was enhanced more effectively by W/O-G emulsion. The results of this study suggest the existence of a special transport mechanism through which drug and oil are delivered together.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01065397
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