ISSN:
1434-193X
Keywords:
Inositolphosphoglycans
;
Oligosaccharide synthesis
;
Insulin mediators
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---A convenient preparative synthesis of 1-D-6-O-(2-amino-2-deoxy-α-D-glycopyranosyl)-chiro-inositol 1-phosphate (III) and -1,2-cyclic phosphate (IV) using D-chiro-inositol as starting material is reported. Compound III has been previously found to behave as type P inositolphosphoglycans (the putative second messengers of insulin-like growth factor I) in organotypic cultures of chicken embryo. The synthesis of III and IV, now reported, considerably improves previous synthesis of III and permits the effective preparation of these substances for biological investigation.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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