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  • 1
    Publication Date: 1974-02-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2011-08-24
    Description: Reflex responses that depend on human otolith organ sensitivity were measured before, during and after a 10 day space flight. Otolith-spinal reflexes were elicited by means of sudden, unexpected falls. In weightlessness, "falls" were achieved using elastic cords running from a torso harness to the floor. Electromyographic (EMG) activity was recorded from gastrocnemius-soleus. The EMG response occurring in the first 100-120 ms of a fall, considered to be predominantly otolith-spinal in origin, decreased in amplitude immediately upon entering weightlessness, and continued to decline throughout the flight, especially during the first two mission days. The response returned to normal before the first post-flight testing session. The results suggest that information coming from the otolith organs is gradually ignored by the nervous system during prolonged space flight, although the possibility that otolith-spinal reflexes are decreased independent of other otolith output pathways cannot be ruled out.
    Keywords: Life Sciences (General)
    Type: Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale (ISSN 0014-4819); Volume 64; 2; 308-15
    Format: text
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  • 3
    Publication Date: 2011-08-24
    Description: Space sickness symptoms were observed by 4 specially trained observers on Spacelab-1. Three reported persistent symptoms, and vomited repeatedly during the first and/or second day of flight. Head movements on all axes were provocative, particularly in pitch and roll. Head acceleration data recorded from 2 symptomatic crewmen showed that after several hours of physical activity in orbit, symptoms appeared, and thereafter both crewmen were compelled to limit head movements. Firm body contact with motionless surfaces helped alleviate symptoms. When crewmembers floated into unfamiliar body orientations in the cabin, inherent ambiguities in static visual orientation cues sometimes produced spatial reorientation episodes which were also provocative. Symptoms largely resembled those of other forms of prolonged motion sickness, superimposed upon other symptoms attributable to fluid shift. All 4 eventually used anti-motion sickness drugs. When they did, vomiting frequency was reduced. By the 4th day, symptoms subsided, and head accelerations again increased in magnitude and variability. Sickness intensity in orbit was not predicted by statistically concordant results of 6 acute preflight susceptibility tests. However, results from a longer duration preflight prism goggles test showed an apparent correlation. All subjects were asymptomatic making head movements in parabolic flight 4 days after the mission, but not 1 year later. Overall, results support the view that space sickness is a motion sickness.
    Keywords: Aerospace Medicine
    Type: Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale (ISSN 0014-4819); Volume 64; 2; 316-34
    Format: text
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  • 4
    Publication Date: 2011-08-24
    Description: Early attempts to develop an animal model for anti-motion sickness drugs, using dogs and cats; were unsuccessful. Dogs did not show a beneficial effect of scopolamine (probably the best single anti-motion sickness drug for humans thus far) and the findings in cats were not definitive. The authors have developed an animal model using the squirrel monkey (Saimiri sciureus) of the Bolivian phenotype. Unrestrained monkeys in a small lucite cage were tested in an apparatus that induces motion sickness by combining vertical oscillation and horizontal rotation in a visually unrestricted laboratory environment. Signs of motion sickness were scored using a rating scale. Ten susceptible monkeys (weighing 800-1000 g) were given a total of five tests each, to establish the baseline susceptibility level. Based on the anticholinergic activity of scopolamine, the sensitivity of squirrel monkey to scopolamine was investigated, and the appropriate dose of scopolamine for this species was determined. Then various anti-motion sickness preparations were administered in subsequent tests: 100 ug scopolamine per monkey; 140 ug dexedrine; 50 ug scopolamine plus 70 ug dexedrine; 100 ug scopolamine plus 140 ug dexedrine; 3 mg promethazine; 3 mg promethazine plus 3 mg ephedrine. All these preparations were significantly effective in preventing motion sickness in the monkeys. Ephedrine, by itself, which is marginally effective in humans, was ineffective in the monkeys at the doses tried (0.3-6.0 mg). The squirrel monkey appears to be a good animal model for antimotion sickness drugs. Peripherally acting antihistamines such as astemizole and terfenadine were found to be ineffective, whereas flunarizine, and an arginine vasopressin V1 antagonist, showed significant activity in preventing motion sickness.
    Keywords: Aerospace Medicine
    Type: Journal of clinical pharmacology (ISSN 0091-2700); Volume 32; 2; 163-75
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  • 5
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    In:  Other Sources
    Publication Date: 2011-08-24
    Description: In the new century there will probably be more long spaceflights and fewer short spaceflights. There will probably be several flights to Mars, flights that (if chemical rockets are used) will involve one year to get there, a second year on Mars, and a third year to return. The three-year Mars scenario will probably include rotation of the spacecraft to provide artificial gravity. If nuclear thermal rockets are used, a manned exploration of Mars could be accomplished in less than one year. Vestibular research will be directed towards ensuring that astronauts, upon landing on Mars, will be able to walk with confidence and without delay. Research will be required to investigate vestibular adaptation in spaceflight, motion sickness, and the vestibular effects of rotation in spaceflight.
    Keywords: Aerospace Medicine
    Type: ORL; journal for oto-rhino-laryngology and its related specialties (ISSN 0301-1569); Volume 55; 3; 173-4
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  • 6
    Publication Date: 2004-10-30
    Keywords: AEROSPACE MEDICINE
    Type: INSI02 Vestibular Experiments on Spacelab-1; 47 p
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  • 7
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    In:  CASI
    Publication Date: 2005-11-13
    Description: Fast tilt test of semicircular canals in cats, and slow tilt and dropping platform tests of otoliths in cats
    Keywords: BIOSCIENCES
    Type: NASA THE ROLE OF THE VESTIBULAR ORGANS IN SPACE EXPLORATION 1968; P 351-354
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  • 8
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    In:  CASI
    Publication Date: 2006-10-26
    Description: Vestibular apparatus and motion sickness problems in rotating spacecraft
    Keywords: BIOSCIENCES
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  • 9
    Publication Date: 2006-10-26
    Description: Labyrinth, otolith, and other vestibular responses to space environment
    Keywords: BIOSCIENCES
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  • 10
    Publication Date: 2004-10-30
    Keywords: AEROSPACE MEDICINE
    Type: MIT INSI02 Vestibular Experiments on Spacelab-1; 19 p
    Format: text
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