ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An improved method for the preparation of Merrifield resin esters is presented. This method is rapid, is free of racemization, and is not complicated by a quaternization side reaction. Chloromethylated resin beads, t-butoxycarbonyl amino acid, and potassium t-butoxide are heated at 80 °C in dimethylsulfoxide for one-half hour to yield resin esters of suitable substitution for solid-phase petide synthesis. All twenty of the BOC protected common amino acids were esterified to the resin by this method. Resin substitution values lie in the range of 0.13 meq/g (BOC-Glu (NH2)) to 0.66 meq/g (BOC/Pro), with most of the amino acids yielding 0.3-0.4 meq/g (on a resin containing 0.8 meq Cl/g).
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1973.360121106
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