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  • 1
    Publication Date: 2020-11-29
    Description: Exotic snakebites (i.e. from non-native species) are a rare occurrence, but they present a unique challenge to clinicians treating these patients. Poison control centers are often contacted to assist in the management and care of these medical emergencies. In this study, we analyzed case records of the two Pennsylvania poison control centers from 2004 to 2018 to describe clinical features reported as a result of exotic snakebite envenomation. For the 15-year period reviewed, 18 exotic snakebites were reported with effects ranging from mild local tissue injury to patients who were treated with mechanical ventilation due to respiratory failure. The mean age of the patients was 35 years and males accounted for 83% of the cases. Antivenom, the only specific treatment, was administered in seven of 18 patients within an average of four h of envenomation. The procurement of antivenom against these exotic species may require substantial logistical efforts due to limited stocking of this rarely used treatment. Newer, targeted, small molecule treatments that are being currently investigated may aid in the treatment of snakebites in general. However, people should be cautious when handling these exotic species, and clinicians should be aware of these bites and relevant clinical effects in order to manage these when reported.
    Electronic ISSN: 2072-6651
    Topics: Chemistry and Pharmacology , Medicine
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  • 2
    Publication Date: 2019-07-13
    Description: A study was performed to determine if a Design of Experiments (DOE)/Response Surface Methodology could be applied to on-orbit thermal analysis and produce a set of Response Surface Equations (RSE) that predict Orion vehicle temperatures within 10 F. The study used the Orion Outer Mold Line model. Five separate factors were identified for study: yaw, pitch, roll, beta angle, and the environmental parameters. Twenty-three external Orion components were selected and their minimum and maximum temperatures captured over a period of two orbits. Thus, there are 46 responses. A DOE case matrix of 145 runs was developed. The data from these cases were analyzed to produce a fifth order RSE for each of the temperature responses. For the 145 cases in the DOE matrix, the agreement between the engineering data and the RSE predictions was encouraging with 40 of the 46 RSEs predicting temperatures within the goal band. However, the verification cases showed most responses did not meet the 10 F goal. After reframing the focus of the study to better align the RSE development with the purposes of the model, a set of RSEs for both the minimum and maximum radiator temperatures was produced which predicted the engineering model output within +/-4 F. Therefore, with the correct application of the DOE/RSE methodology, RSEs can be developed that provide analysts a fast and easy way to screen large numbers of environments and assess proposed changes to the RSE factors.
    Keywords: Fluid Mechanics and Thermodynamics
    Type: JSC-CN-24121 , Thermal and Fluids Analysis Workshop; Aug 15, 2011 - Aug 19, 2011; Hampton, VA; United States
    Format: application/pdf
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  • 3
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    In:  CASI
    Publication Date: 2019-07-13
    Description: An viewgraph presentation of Orion's passive thermal control system is shown. The topics include: 1) Orion in CxP Hierarchy; 2) General Orion Description/Orientation; 3) Module Descriptions and Images; 4) Orion PTCS Overview; 5) Requirements/Interfaces; 6) Design Reference Missions; 7) Natural Environments; 8) Thermal Models; 9) Challenges/Issues; and 10) Testing
    Keywords: Spacecraft Design, Testing and Performance
    Type: TFAWS 2007; Sep 10, 2007 - Sep 14, 2007; Cleveland,OH; United States
    Format: application/pdf
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  • 4
    Publication Date: 2019-07-13
    Description: This slide presentation reviews the study done on alternate attitudes for the Orion project's crew exploration vehicle. The analysis focused on the thermal performance of the vehicle with the alternate attitudes. The pressure vessel heater power, other vehicle heaters and radiator sink temperatures were included in the analysis.
    Keywords: Spacecraft Design, Testing and Performance
    Type: JSC-CN-18526 , TFAWS 2009; Jan 01, 2009 - Jan 14, 2009; Huntsville, AL; United States
    Format: application/pdf
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  • 5
    Publication Date: 2019-07-13
    Description: A study was performed to determine if a Design of Experiments (DOE)/Response Surface Methodology could be applied to on-orbit thermal analysis and produce a set of Response Surface Equations (RSE) that accurately predict vehicle temperatures. The study used an integrated thermal model of the International Space Station and the Orion Outer mold line model. Five separate factors were identified for study: yaw, pitch, roll, beta angle, and the environmental parameters. Twenty external Orion temperatures were selected as the responses. A DOE case matrix of 110 runs was developed. The data from these cases were analyzed to produce an RSE for each of the temperature responses. The initial agreement between the engineering data and the RSE predictions was encouraging, although many RSEs had large uncertainties on their predictions. Fourteen verification cases were developed to test the predictive powers of the RSEs. The verification showed mixed results with some RSE predicting temperatures matching the engineering data within the uncertainty bands, while others had very large errors. While this study to not irrefutably prove that the DOE/RSM approach can be applied to on-orbit thermal analysis, it does demonstrate that technique has the potential to predict temperatures. Additional work is needed to better identify the cases needed to produce the RSEs
    Keywords: Fluid Mechanics and Thermodynamics
    Type: JSC-CN-21202 , 2010 Thermal and Fluids Analysis Workshop; Aug 16, 2010 - Aug 20, 2010; Houston, TX; United States
    Format: application/pdf
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  • 6
    Publication Date: 2019-07-13
    Description: A general overview of the NASA Orion Passive Thermal Control System (PTCS) is presented. The topics include: 1) Orion in CxP Hierarchy; 2) General Orion Description/Orientation; and 3) Orion PTCS Overview.
    Keywords: Spacecraft Propulsion and Power
    Type: JSC-CN-18527 , TFAWS 2009; Aug 10, 2009 - Aug 14, 2009; Huntsville, AL; United States
    Format: application/pdf
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