ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Via the phosphotriester approach, new structural analogs of (2′-5′)oligoadenyiates, namely 3′-deoxyadenylyl-(2′-5′)-3′-dcoxyadenylyl-(2′-ω)-9-(ω-hydroxyalkyl)adenines 18-21, have been synthesized (see Scheme) which should preserve biological activity and show higher stability towards phosphodiesterases. The newly synthesized oligonucleotides 18-21 have been characterized by 1H-NMR spectra, TLC, and HPLC analysis.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19910740419
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