ISSN:
1574-6968
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
In order to evaluate whether lactobacilli could reduce antibiotic-related ecological disturbances of the normal intestinal microflora, rats were treated daily with either lactobacilli (Lactobacillus delbrueckii subsp. bulgaricus + Streptococcus thermophilus, 108 cfu per animal for 6 days), clindamycin (4 mg/kg for 5 days) or a combination of both. The effects upon the following microflora-associated characteristics were evaluated: mucin degradation, conversion of cholesterol to coprostanol, inactivation of tryptic activity, presence of short-chain fatty acids and absence of beta-aspartylglycine.Clindamycin markedly influenced all characteristics except beta-aspartylglycine, resulting in a pattern very much alike what is found in germ-free animals. No significant differences were seen between the group receiving clindamycin + lactobacilli compared to the group receiving clindamycin only, even though the lactobacilli count increased in all animals receiving lactobacilli.We conclude that clindamycin markedly influences and disturbs normal intestinal microflora-related functions and that administration of lactobacilli of the type used in this study has no positive effect on diminishing these disturbances.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-6968.1987.tb02374.x
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