ISSN:
1573-501X
Keywords:
anhydrides
;
assembly
;
chlorotrityl resin
;
combinatorial synthesis
;
diamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial parallel synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009662605993
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