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  • 1
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Purpose - The purpose of this literature review is to examine underlying mechanisms through which soy may affect breast cancer risk. Design/methodology/approach - The approach taken is to summarize the emerging mechanisms of how isoflavones, such as genistein, interact with processes leading to breast cancer. Findings - The key finding of this analysis is that these mechanisms include a multitude of contrasting effects of genistein on estrogenic and non-estrogenic signaling pathways controlling cell growth. Furthermore, several of these mechanisms are also regulated by additional dietary factors, such as omega-3 fatty acids (found e.g. in fish) and various other phytochemicals (factors found generally in plant-based foods). The available mechanistic information supports (i) a potent effect of dietary factors on cell growth and (ii) a synergistic effect of different dietary components, such as soy, fish, and plant-based foods. Practical implications - In conclusion, the practical implication of this analysis is the conclusion that the mechanistic information available at this time does not support a recommendation for an isolated increase in soy to decrease breast cancer risk. Originality/value - This article should be of value for health care providers, nutritionists, and consumers.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Bingley : Emerald
    Nutrition & food science 35 (2005), S. 28-34 
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Purpose - The purpose of this literature review is to examine the relationship between soy consumption and breast cancer risk since soy isoflavones, such as genistein, are currently discussed as possible breast cancer-fighting agents in the Asian diet. Design/methodology/approach - The approach taken is to summarize and evaluate the available literature on the effect of soy, and the Asian diet, on breast cancer risk. Findings - A key finding of the current analysis is that the effect of genistein depends strongly on dosage and developmental stage during which exposure occurs. The overall conclusion and value of this comprehensive analysis is that the available evidence does not support a recommendation for increased soy consumption as a breast cancer-preventing agent against the background of a Western diet. Instead, additional general components of the Asian diet, such as fish and plant-based food, may be involved in lowering breast cancer risk. Research limitations/implications - A limitation to drawing final conclusions at this time is that further research is clearly needed to better understand the overall effect of soy and other dietary factors. Practical implications - The practical implication for health care providers, nutritionists, and consumers is therefore a recommendation to avoid isoflavone supplements and enhanced soy consumption alone at this time without an increased intake of the other Asian diet components. Originality/value - This review arrives at new conclusions about the connection between soy and breast cancer that are summarized under findings and should be valuable for health care providers, nutritionists, and consumers
    Type of Medium: Electronic Resource
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