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  • 1
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The presenilin proteins are components of high–molecular–weight protein complexes in the endoplasmic reticulum and Golgi apparatus that also contain β-catenin. We report here that presenilin mutations associated with familial Alzheimer disease (but not the non–pathogenic ...
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 419 (1976), S. 435-444 
    ISSN: 0005-2736
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Protein Structure 579 (1979), S. 62-72 
    ISSN: 0005-2795
    Keywords: (Semliki Forest virus) ; Concanavalin A-Sepharose ; Glycoprotein
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Advances in Space Research 11 (1991), S. 223-230 
    ISSN: 0273-1177
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Advances in Space Research 6 (1986), S. 37-41 
    ISSN: 0273-1177
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 21 (1998), S. 261-274 
    ISSN: 1476-5535
    Keywords: Keywords: biofilms; stainless steel; Baltic Sea; ennoblement; CLSM; in situ hybridization; fluorescent beads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: ca 400 mV), the biofilm on the steel surface was characterized using confocal laser scanning microscopy (CLSM) in combination with functional and phylogenetic stains. The biofilm consisted of microbial cell clusters covering 10–20% of the surface. The clusters were loaf-formed, with a basal diameter of 20–150 μm, 5–20 per mm−2, each holding 〉104 cells in a density of 1–5 × 107 cells mm−3. The typical cluster contained mainly small Gram-negative bacteria (binding the EUB338 probe when hybridized in situ on the steel surface), and often carried one to three spherical colonies, either homogeneously composed of large Gram-negative cocci or more often small bacterial rods in high density, 108–109 cells mm−3. The clusters in live biofilms contained no pores, and clusters over 25 μm in diameter had a core nonpenetrable to fluorescent nucleic acid stains and ConA lectin stain. Fluorescently-tagged ConA stained cells at a depth of 〈5 μm, indicating the presence of cells with α-d-mannosyl and α-d-glucosyl residues on surfaces. ethidium bromide (log K ow −0.38) penetrated deeper (17 μm in 15 min, corresponding to 〉10 cells in a stack) into the cluster than did the less polar dyes SYTO 16 (log K ow 1.48) and acridine orange (log K ow 1.24), which stained five cells in a stack. Fluorescent hydrophobic and hydrophilic latex beads (diameter 0.02, 0.1 or 1.0 μm) coated patchwise the cluster surface facing the water, but penetrated only to depths of ⩽2 μm indicating a permeability barrier. About 1/3 of the stainable cells hybridized in situ with Alf1b, while fewer than 1/7 hybridized to GAM42, probes targeted towards α- and γ-Proteobacteria, respectively. Our results represent a microscopic description of an ennobling biofilm, where the ennoblement could follow the sequence of redox events as suggested by the model of Dickinson and Lewandowski (1996) for the structure of corrosive biofilms on a steel surface.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 24 (2000), S. 410-420 
    ISSN: 1476-5535
    Keywords: Keywords: biofilm; stainless steel; ennoblement; Baltic Sea; season; laboratory ecosystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Open circuit potentials of stainless steels increased when immersed in the Baltic Sea. The ennoblement potential was +200 mVsce in 40 to 50 days when sea water temperature was below 52°C and +300–400 mVsce within 〈40 days at around 102°C. Ennoblement occurred in a laboratory ecosystem at 232°C in 20 to 30 days, and at 262°C in 〈20 days, but no ennoblement occurred at A322°C within 40 days. By the time the ennoblement was complete, compact microcolonies covered 1–10% of the steel surface. Nutrient enrichment of Baltic Sea water by twofold above the natural levels increased microbial growth but attenuated open circuit potential increase of the stainless steels. Exposure of the ennobled stainless steels to similar levels of nutrients did not reverse the already developed open circuit potentials. Attenuation of the ennobling response of the stainless steels by increases of temperature and eutrophication suggests a role for microorganisms which is crucial for the electrochemical behaviour of steels in brackish Baltic Sea water. Journal of Industrial Microbiology & Biotechnology (2000) 24, 410–420.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 52 (1997), S. 437-440 
    ISSN: 1432-1041
    Keywords: Key words Therapeutic tradition ; Finland ; Estonia; general practice ; international comparison ; primary care doctors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To compare ratings of the necessity of drugs in the daily practice of experienced primary care doctors in Estonia and Finland to find out the differences and similarities in the therapeutic traditions of the two different societies. Methods: A questionnaire was sent to all Estonian district doctors born in the 1940s and to all Finnish specialized general practitioners born in the 1940s, who then evaluated the necessity of the listed drugs on a visual analogue scale. The ratings, from 0 to 100, were entered into a computer, using a graphic tablet and a pressure sensitive pointer. Results: The six most highly-evaluated drugs among the Estonian respondents were digoxin, glyceryl trinitrate, aspirin, calcium-channel blockers, beta-adrenoceptor blockers and frusemide; and among the Finnish general practitioners (GPs) were penicillin, insulin, glyceryl trinitrate, beta-adrenoceptor blockers, frusemide and angiotensin-converting enzyme (ACE) inhibitors. The ratings of 15 out of 33 drugs/drug groups were very similar both in Estonia and Finland. The biggest differences between the opinions of the Estonian and Finnish doctors appeared in the ratings regarding the necessity of antacids, cimetidine, insulin, sulphonylureas, reserpine, ACE inhibitors, oral contraceptives, penicillin, metronidazole, trimethoprim, indomethacin, phenobarbital and theophylline. Conclusion: The revealed differences are suggested to be related to the different health care systems (different task profiles of doctors, different pharmaceutical services), different education of doctors, different availability of drugs in the past and different prices, all of which influence therapeutic traditions.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 224 (1995), S. 585-586 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We searched for the CSJ = 2 − 1 emission towards 29 southern H2O and H2O/OH masers and 1 OH maser with the SEST radio telescope. We detected and mapped 24 CS emitting regions probably associated with 27 H2O masers. The C34SJ = 2 − 1 and COJ = 1 − 0 lines were also observed at the grid positions closest to the CS peaks. Four cores were mapped in the CSJ = 5 − 4 and C34SJ = 2 − 1 lines.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 171 (1990), S. 219-221 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The ε Cha I dark cloud is a nearby (140 pc) site of low-mass star formation. Due to its high galactic latitude (b=−16°) it is an observationally favourable object for study at radio as well as other wavelengths. We have mapped the central part of the cloud in the C18O (1–0) line using both the 1.2-m Columbia Southern Millimeter-Wave Telescope at Cerro Tololo and the 15-m Swedish-ESO Submillimetre Telescope (SEST).
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