Publication Date:
2015-08-21
Description:
Article Intrinsically disordered proteins can phase separate from the soluble intracellular space. Here the authors show that the nucleic acid-mimicking biopolymer poly(ADP-ribose) (PAR) nucleates intracellular liquid demixing and orchestrates the earliest cellular responses to DNA breakage. Nature Communications doi: 10.1038/ncomms9088 Authors: Matthias Altmeyer, Kai J. Neelsen, Federico Teloni, Irina Pozdnyakova, Stefania Pellegrino, Merete Grøfte, Maj-Britt Druedahl Rask, Werner Streicher, Stephanie Jungmichel, Michael Lund Nielsen, Jiri Lukas
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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