ISSN:
1573-4927
Keywords:
NADP-malate dehydroenase-like enzyme (MDL-1)
;
polymorphism
;
linkage group IV
;
inbred rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract A new polymorphism in the mitochondrial fraction of kidney homogenates was found by using discontinuous polyacrylamide gel electrophoresis. The polymorphism is tentatively designated MDL-1, since the enzyme was visualized with the staining solution for NADP-malate dehydrogenase (MOD) but differs from MOD. MDL-1 expresses three phenotypes: MDL-1A (fast), MDL-1 AB (intermediate), and MDL-1B (slow). Progeny testing from genetic crosses indicates that its expression is determined by two codominant alleles, Mdl-1a and Mdl-1b, which segregate in a simple Mendelian fashion. Preliminary linkage data suggest that the locus for MDL-1 is probably linked to the nonagouti-agouti locus in rat linkage group IV.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00484695
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