Publication Date:
2016-05-19
Description:
Reproducible pharmacogenomic profiling of cancer cell line panels Nature 533, 7603 (2016). doi:10.1038/nature17987 Authors: Peter M. Haverty, Eva Lin, Jenille Tan, Yihong Yu, Billy Lam, Steve Lianoglou, Richard M. Neve, Scott Martin, Jeff Settleman, Robert L. Yauch & Richard Bourgon The use of large-scale genomic and drug response screening of cancer cell lines depends crucially on the reproducibility of results. Here we consider two previously published screens, plus a later critique of these studies. Using independent data, we show that consistency is achievable, and provide a systematic description of the best laboratory and analysis practices for future studies.
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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