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  • 1
    Electronic Resource
    Electronic Resource
    Joining of SiC Ceramic to High Strength Graphite Using Polysiloxane with Active Additive (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2092-2095 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In order to contribute to the development of the joining technique of Cf/SiC, joining ofSiC ceramic to high strength graphite was investigated. This joining has been successfully realizedby reaction joining process using a preceramic polymer, polysiloxane, mixed with the activeadditive Al-Si powder as joining material. The weld strength is strongly affected by thetechnological parameters and the ingredient ratio (polysiloxane:Al-Si powder). The optimizedfactors have been obtained by orthogonal experiments, under which the achieved three-pointbending strength of the joints is 96.8% of the strength of the welding base material graphite. Themicrostructure and composition of the weld zone were analyzed by SEM, EDX and XRD. Theresults show that the joining material has transformed into a densified interlayer with the thicknessof about 15μm. Also, diffusion takes place in the interfacial area, which contributes to a soundinterfacial bonding. The interlayer is composed of SiC, Al2O3 and Si
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.2092.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Wettability of Graphite/Ni plus Cr System (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 1621-1624 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Carbon fiber reinforced CMCs (ceramic matrix composites) are promising high temperaturestructural materials for aeronautical and astronautical industries. But the engineering application of thematerials strongly depends on the joining technique. As a fundamental research, high strength graphitecan be used to simulate carbon fiber. The study of wettability of graphite by liquid metals contributes tothe development of joining technique of carbon fiber reinforced CMCs. The wettability of graphite/Niplus Cr system was investigated using the sessile drop method. The contact angle was determined by hightemperature photography. The microstructure and composition of the interfacial zone were analyzed bySEM, EDX and XRD. The contact angle of graphite/Ni plus Cr system decreases with increasing the Crcontent. It becomes zero, when the Cr content reaches 50wt%. The wetting of graphite/Ni plus Cr systemis chemical wetting. The contact angle of the system decreases with increasing the wetting temperature orprolonging the holding time. The higher the Cr content, the more remarkable the effects of thetemperature and the holding time on the contact angle are. Microstructure and phase analysis reveals thatinter-diffusions and interfacial reactions take place in the wetting process. The reaction products includeCr3C2. The formation of Cr3C2 contributes to the interfacial bonding and results in the accumulation of Crin the interfacial zone
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.1621.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Preparation of SiOC Foam Ceramics Using Polysiloxane (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 920-922 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The SiOC foam ceramics were prepared using polyurethane sponge and polysiloxane as rawmaterials. The effects of the pyrolysis temperature, the concentration of polysiloxane solutions, and thecontent of SiC nano-powder on compression strength of the SiOC foam ceramics have been investigatedrespectively. The optimum compression strength of SiOC foam ceramics is obtained at the pyrolysistemperature of 1250ºC and the concentration of solution PSO of 0.8 g/ml. Adding SiC nano-powder intoPSO can effectively increase compression strength of samples, and the maximum compression strength,20.8 MPa, is obtained when the content of SiC nano-powder is 5 wt%. Microstructural study reveals thatthe foam ceramics have an open, uniform and interconnected porous structure with high porosity of 80%
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.920.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Joining of SiC Ceramic to Graphite Using Ni-51Cr Powders as Filler (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 1600-1602 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Joining of SiC ceramic to graphite is important from both technical and economical points ofview. High temperature brazing of recrystallized SiC ceramic to high strength graphite has been realizedusing Ni-51Cr (consisting of Ni + 51wt% Cr powders) powders as filler. The obtained maximumthree-point bending strength of joints is 32.3MPa, which is equal to 80.8% of the strength of the graphite.Microstructure and phase analysis reveals that interdiffusions and chemical reactions take place in theweld zone. A reaction layer and an interlayer form in the interfacial area. The reaction layer, of which thethickness is about 60-100μm, is contacted with the SiC ceramic. The interlayer with the thickness ofabout 200μm exists between the graphite and the reaction layer. The reaction layer is mainly composed ofNi2Si, while the interlayer is mainly composed of Cr23C6 and Ni2Si
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.1600.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Joining of SiC Ceramic by High Temperature Brazing Using Ni-Cr-SiC Powders as Filler (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 2394-2397 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Joining of ceramics is of importance from both technical and economical points of view.Brazing is a widely used process to join ceramics. In order to increase the working temperature and weldstrength of joints, a high temperature brazing process using Ni-Cr-SiC powders (consisting of Ni, Cr andSiC powders) as filler to join recrystallized SiC ceramic has been investigated. The obtained optimizedtechnological parameters are joining temperature of 1360°C, holding time of 5min and filler mass of280mg. Under these conditions the maximum relative bending strength of joints, 70.5%, is achieved.Microstructure and phase analysis reveals that interdiffusions and chemical reactions take place in theweld zone. A reaction layer, of which the major phase is Ni2Si, exists between the welding base materialSiC ceramic and the filler reaction product layer, called as interlayer, of which the major phase is Cr23C6
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.2394.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Joining of SiC Ceramic by Hot Pressing Reaction Joining Process Using Ni-51Cr Powders as Filler (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 2398-2401 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Joining of ceramics is of importance from both technical and economical points of view.Joining of recrystallized SiC ceramic to itself has been realized by hot pressing reaction joining processusing Ni-51Cr powders (consisting of Ni+51wt%Cr powders) as filler. The optimized technologicalparameters have been obtained by orthogonal experiment, which are joining temperature of 1150°C,holding time of 20min, joining pressure of 10MPa and cooling rate of 0.25°C/s. The most effective factorto influence the weld strength is joining pressure within the range of testing. Under the optimizedconditions, the maximum relative bending strength of joint, 70.7%, is achieved. The microstructure andphase composition of the weld zone were examined by SEM, EDX and XRD. The results show thatinterdiffusions and chemical reactions take place in the joining process. A reaction layer, which is mainlycomposed of Ni2Si and Ni3C with a little Cr, exists between the welding base material SiC ceramic andthe filler reaction product layer called as interlayer, which is mainly composed of Ni2Si and Cr
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.2398.pdf
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  • 7
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    c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells (2015)
    Wiley
    Details
    Publication Date: 2015-04-30
    Description: Carbon monoxide (CO), a reaction product of the cytoprotective heme oxygenase (HO)-1, displays an anti-inflammatory effect in various cellular injuries, but the precise mechanisms of HO-1 expression remain unknown. We used the transition metal carbonyl compound carbon monoxide-releasing molecule-2 (CORM-2) that acts as carbon monoxide donor. The effects of CORM-2 on expression of HO-1 in human tracheal smooth muscle cells (HTSMCs) were determined by Western blot, real-time PCR, and promoter activity assay. In HTSMCs, CORM-2 activated Nrf2 through the activation of a c-Src/EGFR/PI3K/Akt-dependent pathway, resulting in HO-1 expression. We showed that CORM-2-induced HO-1 protein and mRNA levels were inhibited by the inhibitor of c-Src (PP1 or SU6656), EGFR (AG1478), PI3K (LY294002), Akt (SH-5), JNK1/2 (SP600125), or p38 MAPK (SB202190) and transfection with siRNA of c-Src, EGFR, Akt, p38, JNK2, or Nrf2 in HTSMCs. We also showed that CORM-2 stimulated c-Src, EGFR, Akt, p38 MAPK, and JNK1/2 phosphorylation. CORM-2 also enhanced Nrf2 translocation from the cytosol to the nucleus and antioxidant response element (ARE) promoter activity. Moreover, CORM-2 mediated p38 MAPK and JNK1/2 activation via a c-Src/EGFR/PI3K/Akt pathway, which further enhanced Nrf2 activation and translocation. Finally, we observed that CORM-2 induced in vivo binding of Nrf2 to the HO-1 promoter. CORM-2 activates the c-Src/EGFR/PI3K/Akt/JNK1/2 and p38 MAPK pathways, which in turn trigger Nrf2 activation and ultimately induces HO-1 expression in HTSMCs. Thus, the HO-1/CO system might be potential therapeutics in airway diseases. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 8
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    Selective Cross-Dehydrogenative C(sp3)–H Arylation with Arenes (2020)
    American Chemical Society
    Details
    Publication Date: 2020-03-03
    Print ISSN: 1523-7060
    Electronic ISSN: 1523-7052
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society
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  • 9
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    Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding (2019)
    National Academy of Sciences
    Details
    Publication Date: 2019-11-18
    Description: Chronic kidney disease (CKD) affects more than 20 million Americans and ∼10% of the population worldwide. Genome-wide association studies (GWAS) of kidney functional decline have identified genes associated with CKD, but the precise mechanisms by which they influence kidney function remained largely unexplored. Here, we examine the role of 1 GWAS-identified gene by creating mice deficient for Galnt11, which encodes a member of the enzyme family that initiates protein O-glycosylation, an essential posttranslational modification known to influence protein function and stability. We find that Galnt11-deficient mice display low-molecular-weight proteinuria and have specific defects in proximal tubule-mediated resorption of vitamin D binding protein, α1-microglobulin, and retinol binding protein. Moreover, we identify the endocytic receptor megalin (LRP2) as a direct target of Galnt11 in vivo. Megalin in Galnt11-deficient mice displays reduced ligand binding and undergoes age-related loss within the kidney. Differential mass spectrometry revealed specific sites of Galnt11-mediated glycosylation within mouse kidney megalin/LRP2 that are known to be involved in ligand binding, suggesting that O-glycosylation directly influences the ability to bind ligands. In support of this, recombinant megalin containing these sites displayed reduced albumin binding in cells deficient for Galnt11. Our results provide insight into the association between GALNT11 and CKD, and identify a role for Galnt11 in proper kidney function.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Mapping a major QTL responsible for dwarf architecture in Brassica napus using a single-nucleotide polymorphism marker approach (2016)
    BioMed Central
    Details
    Publication Date: 2016-08-20
    Description: Key genes related to plant type traits have played very important roles in the “green revolution” by increasing lodging resistance and elevating the harvest indices of crop cultivars. Although there have been ...
    Electronic ISSN: 1471-2229
    Topics: Biology
    Published by BioMed Central
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