Publication Date:
2012-12-12
Description:
Na+-K+-ATPase (NKA) establishes the transmembrane [Na+] gradient in cells. In heart, phospholemman (PLM) inhibits NKA activity by reducing its apparent Na+ affinity, an effect that is relieved by PLM phosphorylation. The NKA crystal structure suggests regions of PLM–NKA interaction, but the sites important for functional effects in live cells are...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
Permalink