Publication Date:
2019
Description:
〈p〉The genetic variation of rice cultivars provides a resource for further varietal improvement through breeding. Some rice varieties are sensitive to benzobicyclon (BBC), a β-triketone herbicide that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD). Here we identify a rice gene, 〈i〉HIS1〈/i〉 (〈i〉HPPD INHIBITOR SENSITIVE 1〈/i〉), that confers resistance to BBC and other β-triketone herbicides. We show that 〈i〉HIS1〈/i〉 encodes an Fe(II)/2-oxoglutarate–dependent oxygenase that detoxifies β-triketone herbicides by catalyzing their hydroxylation. Genealogy analysis revealed that BBC-sensitive rice variants inherited a dysfunctional 〈i〉his1〈/i〉 allele from an 〈i〉indica〈/i〉 rice variety. Forced expression of 〈i〉HIS1〈/i〉 in 〈i〉Arabidopsis〈/i〉 conferred resistance not only to BBC but also to four additional β-triketone herbicides. 〈i〉HIS1〈/i〉 may prove useful for breeding herbicide-resistant crops.〈/p〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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