ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Catabolic intermediates of sodium dipropylacetate, an anticonvulsant drug, in the urine extracts of the drug-treated rats were examined by the aid of gas chromatography mass spectrometry. Eleven drug-specific peaks were estimated as unmetabolized sodium dipropylacetate, succinic acid, 2-n-propyl-3-hydroxypentanoic acid, 2-n-propyl-4-hydroxypentanoic acid, 2-n-propyl-3-oxopentanoic acid, 2-n-propyl-5-hydroxypentanoic acid, adipic acid, 2-n-propylglutaric acid, dipropylacetic acid glucuronide, propionic acid and 3-heptanone. Administration of sodium dipropylacetate with isoleucine to rats resulted in the disappearance of 2-n-propyl-3-oxopentanoic acid and a considerable decrease in 2-n-propyl-3-hydroxypentanoic acid. These data indicated that β-oxidation was involved in the metabolism of sodium dipropylacetate as well as glucuronide conjugation and ω-oxidation.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200030509
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