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  • 1
    Electronic Resource
    Electronic Resource
    A reading of Hobbes' Leviathan with economists' glasses (2000)
    Bingley : Emerald
    International journal of social economics 27 (2000), S. 134-146 
    Details
    ISSN: 0306-8293
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The purpose of this article is to show the central role of Thomas Hobbes in the formation of capitalist ideology. He is the first author to present the ideology of the businessman (homo oeconomicus), with its most distinctive characteristic, individualism. Every constitutive element of the capitalist system is found in Hobbes' writings. His mentality is bourgeois and he uses a model that can only correspond to a mercantile society of capitalist character, in which political rights are less important than security in the market. The economic liberalism of Adam Smith inherits from Hobbes its individualistic basis and its chrematistic platform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/03068290010253065
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    Paper (German National Licenses)
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  • 2
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    Molecular biology: RNA interference hangs by a thread (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaratiegui, Mikel -- England -- Nature. 2015 Apr 9;520(7546):162-4. doi: 10.1038/nature14376. Epub 2015 Mar 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Biochemistry, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25807482" target="_blank"〉PubMed〈/a〉
    Keywords: Multiprotein Complexes/*metabolism ; *RNA Interference ; RNA, Small Interfering/*genetics ; Schizosaccharomyces/*genetics/*metabolism ; Schizosaccharomyces pombe Proteins/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-10-18
    Description: Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification during the DNA replication phase of the cell cycle. Here we show that the alternating arrangement of origins of replication and non-coding RNA in pericentromeric heterochromatin results in competition between transcription and replication in Schizosaccharomyces pombe. Co-transcriptional RNAi releases RNA polymerase II (Pol II), allowing completion of DNA replication by the leading strand DNA polymerase, and associated histone modifying enzymes that spread heterochromatin with the replication fork. In the absence of RNAi, stalled forks are repaired by homologous recombination without histone modification.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391703/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391703/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaratiegui, Mikel -- Castel, Stephane E -- Irvine, Danielle V -- Kloc, Anna -- Ren, Jie -- Li, Fei -- de Castro, Elisa -- Marin, Laura -- Chang, An-Yun -- Goto, Derek -- Cande, W Zacheus -- Antequera, Francisco -- Arcangioli, Benoit -- Martienssen, Robert A -- R01 GM076396/GM/NIGMS NIH HHS/ -- R01 GM076396-04/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Oct 16;479(7371):135-8. doi: 10.1038/nature10501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22002604" target="_blank"〉PubMed〈/a〉
    Keywords: Centromere/genetics/metabolism ; Chromosomal Proteins, Non-Histone/genetics/metabolism ; DNA Damage ; DNA Replication/*physiology ; DNA-Directed DNA Polymerase/metabolism ; *Gene Silencing ; Heterochromatin/*genetics/*metabolism ; Histones/metabolism ; Homologous Recombination ; Models, Genetic ; Molecular Sequence Data ; *RNA Interference ; RNA Polymerase II/*metabolism ; RNA, Small Interfering/genetics/metabolism ; Replication Origin ; S Phase ; Schizosaccharomyces/*genetics ; Schizosaccharomyces pombe Proteins/genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-12-15
    Description: Centromere-binding protein B (CENP-B) is a widely conserved DNA binding factor associated with heterochromatin and centromeric satellite repeats. In fission yeast, CENP-B homologues have been shown to silence long terminal repeat (LTR) retrotransposons by recruiting histone deacetylases. However, CENP-B factors also have unexplained roles in DNA replication. Here we show that a molecular function of CENP-B is to promote replication-fork progression through the LTR. Mutants have increased genomic instability caused by replication-fork blockage that depends on the DNA binding factor switch-activating protein 1 (Sap1), which is directly recruited by the LTR. The loss of Sap1-dependent barrier activity allows the unhindered progression of the replication fork, but results in rearrangements deleterious to the retrotransposon. We conclude that retrotransposons influence replication polarity through recruitment of Sap1 and transposition near replication-fork blocks, whereas CENP-B counteracts this activity and promotes fork stability. Our results may account for the role of LTR in fragile sites, and for the association of CENP-B with pericentromeric heterochromatin and tandem satellite repeats.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057531/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057531/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaratiegui, Mikel -- Vaughn, Matthew W -- Irvine, Danielle V -- Goto, Derek -- Watt, Stephen -- Bahler, Jurg -- Arcangioli, Benoit -- Martienssen, Robert A -- A6517/Cancer Research UK/United Kingdom -- C9546/A6517/Cancer Research UK/United Kingdom -- R01 GM076396/GM/NIGMS NIH HHS/ -- R01 GM076396-01A1/GM/NIGMS NIH HHS/ -- R01GM076396/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Jan 6;469(7328):112-5. doi: 10.1038/nature09608. Epub 2010 Dec 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21151105" target="_blank"〉PubMed〈/a〉
    Keywords: Centromere Protein B/deficiency/genetics/*metabolism ; Chromosomal Proteins, Non-Histone/genetics/metabolism ; Conserved Sequence/genetics ; DNA Damage/genetics ; DNA Replication/*genetics ; DNA-Binding Proteins/genetics/metabolism ; Genome, Fungal/*genetics ; Genomic Instability/*genetics ; Recombination, Genetic ; Retroelements/*genetics ; Schizosaccharomyces/*genetics/metabolism ; Schizosaccharomyces pombe Proteins/genetics/metabolism ; Terminal Repeat Sequences/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Argonaute slicing is required for heterochromatic silencing and spreading (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-08-26
    Description: Small interfering RNA (siRNA) guides dimethylation of histone H3 lysine-9 (H3K9me2) via the Argonaute and RNA-dependent RNA polymerase complexes, as well as base-pairing with either RNA or DNA. We show that Argonaute requires the conserved aspartate-aspartate-histidine motif for heterochromatic silencing and for ribonuclease H-like cleavage (slicing) of target messages complementary to siRNA. In the fission yeast Schizosaccharomyces pombe, heterochromatic repeats are transcribed by polymerase II. We show that H3K9me2 spreads into silent reporter genes when they are embedded within these transcripts and that spreading requires read-through transcription, as well as slicing by Argonaute. Thus, siRNA guides histone modification by basepairing interactions with RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Irvine, Danielle V -- Zaratiegui, Mikel -- Tolia, Niraj H -- Goto, Derek B -- Chitwood, Daniel H -- Vaughn, Matthew W -- Joshua-Tor, Leemor -- Martienssen, Robert A -- R01 GM076396/GM/NIGMS NIH HHS/ -- R01 GM076396-01A1/GM/NIGMS NIH HHS/ -- R01-GM067014/GM/NIGMS NIH HHS/ -- R01-GM072659/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 25;313(5790):1134-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16931764" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Argonaute Proteins ; Base Pairing ; Genes, Reporter ; Heterochromatin/genetics/*metabolism ; Histones/metabolism ; *RNA Interference ; RNA, Fungal/*metabolism ; RNA, Messenger/metabolism ; RNA, Small Interfering/*metabolism ; RNA-Binding Proteins ; Recombinant Fusion Proteins/metabolism ; Schizosaccharomyces/*genetics/metabolism ; Schizosaccharomyces pombe Proteins/chemistry/genetics/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Arrested replication forks guide retrotransposon integration (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-09-26
    Description: Long terminal repeat (LTR) retrotransposons are an abundant class of genomic parasites that replicate by insertion of new copies into the host genome. Fungal LTR retrotransposons prevent mutagenic insertions through diverse targeting mechanisms that avoid coding sequences, but conserved principles guiding their target site selection have not been established. Here, we show that insertion of the fission yeast LTR retrotransposon Tf1 is guided by the DNA binding protein Sap1 and that the efficiency and location of the targeting depend on the activity of Sap1 as a replication fork barrier. We propose that Sap1 and the fork arrest it causes guide insertion of Tf1 by tethering the integration complex to target sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacobs, Jake Z -- Rosado-Lugo, Jesus D -- Cranz-Mileva, Susanne -- Ciccaglione, Keith M -- Tournier, Vincent -- Zaratiegui, Mikel -- 1R01GM105831/GM/NIGMS NIH HHS/ -- 5T32GM008339/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Sep 25;349(6255):1549-53. doi: 10.1126/science.aaa3810.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Nelson A133, 604 Allison Road, Piscataway, NJ 08854, USA. ; Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Nelson A133, 604 Allison Road, Piscataway, NJ 08854, USA. zaratiegui@dls.rutgers.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26404838" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA Replication ; DNA-Binding Proteins/genetics/*metabolism ; *Mutagenesis, Insertional ; Retroelements/*genetics ; Schizosaccharomyces/*genetics ; Schizosaccharomyces pombe Proteins/genetics/*metabolism ; Terminal Repeat Sequences/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    CLRC organization and Dos1 crystal structure [Biochemistry] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-02-05
    Description: Repressive histone H3 lysine 9 methylation (H3K9me) and its recognition by HP1 proteins are necessary for pericentromeric heterochromatin formation. In Schizosaccharomyces pombe, H3K9me deposition depends on the RNAi pathway. Cryptic loci regulator 4 (Clr4), the only known H3K9 methyltransferase in this organism, is a subunit of the Clr4 methyltransferase complex...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Liver transduction with a simian virus 40 vector encoding insulin-like growth factor I reduces hepatic damage and the development of liver cirrhosis (2006)
    Springer Nature
    Details
    Publication Date: 2006-10-05
    Print ISSN: 0969-7128
    Electronic ISSN: 1476-5462
    Topics: Biology , Medicine
    Published by Springer Nature
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