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  • 1
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    Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-07
    Description: Lnc2Cancer ( http://www.bio-bigdata.net/lnc2cancer ) is a manually curated database of cancer-associated long non-coding RNAs (lncRNAs) with experimental support that aims to provide a high-quality and integrated resource for exploring lncRNA deregulation in various human cancers. LncRNAs represent a large category of functional RNA molecules that play a significant role in human cancers. A curated collection and summary of deregulated lncRNAs in cancer is essential to thoroughly understand the mechanisms and functions of lncRNAs. Here, we developed the Lnc2Cancer database, which contains 1057 manually curated associations between 531 lncRNAs and 86 human cancers. Each association includes lncRNA and cancer name, the lncRNA expression pattern, experimental techniques, a brief functional description, the original reference and additional annotation information. Lnc2Cancer provides a user-friendly interface to conveniently browse, retrieve and download data. Lnc2Cancer also offers a submission page for researchers to submit newly validated lncRNA-cancer associations. With the rapidly increasing interest in lncRNAs, Lnc2Cancer will significantly improve our understanding of lncRNA deregulation in cancer and has the potential to be a timely and valuable resource.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉How hexanucleotide GGGGCC (G〈sub〉4〈/sub〉C〈sub〉2〈/sub〉) repeat expansions in 〈i〉C9orf72〈/i〉 cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is not understood. We developed a mouse model engineered to express poly(PR), a proline-arginine (PR) dipeptide repeat protein synthesized from expanded G〈sub〉4〈/sub〉C〈sub〉2〈/sub〉 repeats. The expression of green fluorescent protein–conjugated (PR)〈sub〉50〈/sub〉 (a 50-repeat PR protein) throughout the mouse brain yielded progressive brain atrophy, neuron loss, loss of poly(PR)-positive cells, and gliosis, culminating in motor and memory impairments. We found that poly(PR) bound DNA, localized to heterochromatin, and caused heterochromatin protein 1α (HP1α) liquid-phase disruptions, decreases in HP1α expression, abnormal histone methylation, and nuclear lamina invaginations. These aberrations of histone methylation, lamins, and HP1α, which regulate heterochromatin structure and gene expression, were accompanied by repetitive element expression and double-stranded RNA accumulation. Thus, we uncovered mechanisms by which poly(PR) may contribute to the pathogenesis of 〈i〉C9orf72〈/i〉-associated FTD and ALS.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Windows open for highly tunable magnetostructural phase transitions (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-07-19
    Description: An attempt was made to tailor the magnetostructural transitions over a wide temperature range under the principle of isostructural alloying. A series of wide Curie-temperature windows (CTWs) with a maximal width of 377 K between 69 and 446 K were established in the Mn 1− y Co y NiGe 1− x Si x system. Throughout the CTWs, the magnetic-field-induced metamagnetic behavior and giant magnetocaloric effects are obtained. The (Mn,Co)Ni(Ge,Si) system shows great potential as multifunctional phase-transition materials that work in a wide range covering liquid-nitrogen and above water-boiling temperatures. Moreover, general understanding of isostructural alloying and CTWs constructed in (Mn,Co)Ni(Ge,Si) as well as (Mn,Fe)Ni(Ge,Si) is provided.
    Electronic ISSN: 2166-532X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by American Institute of Physics (AIP)
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  • 4
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    Site preference and compensation behavior in Co(Cr, Mn)2O4 system (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-04-16
    Description: Site preference of doped Mn ions in CoCr 2−x Mn x O 4 (x = 0–2) series has been derived separately from structure and magnetic measurement. It shows that parts of the doped Mn ions occupy the A (Co) sites when x 
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 5
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    Study of the LiFePO4/FePO4Two-Phase System by High-Resolution Electron Energy Loss Spectroscopy (2006)
    American Chemical Society
    Details
    Publication Date: 2006-11-01
    Print ISSN: 0897-4756
    Electronic ISSN: 1520-5002
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by American Chemical Society
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  • 6
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    Phylogenomics and Evolutionary Dynamics of the Family Actinomycetaceae (2014)
    Oxford University Press
    Details
    Publication Date: 2014-10-09
    Description: The family Actinomycetaceae comprises several important pathogens that impose serious threat to human health and cause substantial infections of economically important animals. However, the phylogeny and evolutionary dynamic of this family are poorly characterized. Here, we provide detailed description of the genome characteristics of Trueperella pyogenes , a prevalent opportunistic bacterium that belongs to the family Actinomycetaceae , and the results of comparative genomics analyses suggested that T. pyogenes was a more versatile pathogen than Arcanobacterium haemolyticum in adapting various environments. We then performed phylogenetic analyses at the genomic level and showed that, on the whole, the established members of the family Actinomycetaceae were clearly separated with high bootstrap values but confused with the dominant genus Actinomyces , because the species of genus Actinomyces were divided into three main groups with different G+C content. Although T. pyogenes and A. haemolyticum were found to share the same branch as previously determined, our results of single nucleotide polymorphism tree and genome clustering as well as predicted intercellular metabolic analyses provide evidence that they are phylogenetic neighbors. Finally, we found that the gene gain/loss events occurring in each species may play an important role during the evolution of Actinomycetaceae from free-living to a specific lifestyle.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    Memory in chemotaxis [Cell Biology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-10-08
    Description: Natural chemical gradients to which cells respond chemotactically are often dynamic, with both spatial and temporal components. A primary example is the social amoeba Dictyostelium, which migrates to the source of traveling waves of chemoattractant as part of a self-organized aggregation process. Despite its physiological importance, little is known about...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Tau suppression in a neurodegenerative mouse model improves memory function (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-16
    Description: Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574647/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574647/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santacruz, K -- Lewis, J -- Spires, T -- Paulson, J -- Kotilinek, L -- Ingelsson, M -- Guimaraes, A -- DeTure, M -- Ramsden, M -- McGowan, E -- Forster, C -- Yue, M -- Orne, J -- Janus, C -- Mariash, A -- Kuskowski, M -- Hyman, B -- Hutton, M -- Ashe, K H -- P01 AG015453/AG/NIA NIH HHS/ -- P01-AG15453/AG/NIA NIH HHS/ -- R01 AG008487/AG/NIA NIH HHS/ -- R01 AG026249/AG/NIA NIH HHS/ -- R01 AG026252/AG/NIA NIH HHS/ -- R01 NS033249/NS/NINDS NIH HHS/ -- R01 NS046355/NS/NINDS NIH HHS/ -- R01-026252/PHS HHS/ -- R01-AG08487/AG/NIA NIH HHS/ -- R01-AG26249/AG/NIA NIH HHS/ -- R01-NS46355/NS/NINDS NIH HHS/ -- T31-AG00277/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):476-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020737" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Atrophy ; Brain/*metabolism/pathology ; Cognition ; Disease Progression ; Doxycycline/pharmacology ; Hippocampus/metabolism/pathology ; Humans ; Maze Learning ; *Memory ; Mice ; Mice, Transgenic ; Neurodegenerative Diseases/metabolism/*pathology/*physiopathology ; Neurofibrillary Tangles/metabolism/*pathology ; Neuronal Plasticity ; Neurons/metabolism/pathology ; Organ Size ; Phosphorylation ; RNA, Messenger/genetics/metabolism ; Solubility ; tau Proteins/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-09
    Description: The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. In order to observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter. Using these probes to image dopamine release in the striatum, we made several observations pertinent to synaptic plasticity. We found that the fraction of synaptic vesicles releasing neurotransmitter per stimulus was dependent on the stimulus frequency. A kinetically distinct "reserve" synaptic vesicle population was not observed under these experimental conditions. A frequency-dependent heterogeneity of presynaptic terminals was revealed that was dependent in part on D2 dopamine receptors, indicating a mechanism for frequency-dependent coding of presynaptic selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gubernator, Niko G -- Zhang, Hui -- Staal, Roland G W -- Mosharov, Eugene V -- Pereira, Daniela B -- Yue, Minerva -- Balsanek, Vojtech -- Vadola, Paul A -- Mukherjee, Bipasha -- Edwards, Robert H -- Sulzer, David -- Sames, Dalibor -- R01 DA007418/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1441-4. doi: 10.1126/science.1172278. Epub 2009 May 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Columbia University, New York, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423778" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benz(a)Anthracenes/*metabolism ; Cells, Cultured ; Chromaffin Cells/*metabolism ; Corpus Striatum/cytology/*metabolism ; Dopamine/*metabolism ; Dopamine Antagonists/pharmacology ; Dopamine D2 Receptor Antagonists ; Electric Stimulation ; Exocytosis ; Fluorescent Dyes ; Mice ; Mice, Transgenic ; Neuronal Plasticity ; Neurotransmitter Agents/*metabolism ; Presynaptic Terminals/*metabolism ; Receptors, Dopamine D2/metabolism ; Sulpiride/pharmacology ; Synaptic Vesicles/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Laser Cladding Synthesis of Ta 2 O 5 Coatings on a Ta Substrate (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-10-04
    Description: A five-layer overlaid Ta 2 O 5 dense ceramic coating was successfully fabricated on a pure Ta substrate using laser cladding. The coating exhibits a graded microstructure with a single phase of α-Ta 2 O 5 formed towards the top of the coating, and was metallurgically bonded to the Ta substrate. Both the coating and the coating-substrate interface region were free from porosity. The development of the coating’s microstructure was discussed based on an existing Ta-O phase diagram.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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