Publication Date:
1993-06-18
Description:
CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erard, F -- Wild, M T -- Garcia-Sanz, J A -- Le Gros, G -- New York, N.Y. -- Science. 1993 Jun 18;260(5115):1802-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Allergy/Immunology, Ciba-Geigy Ltd., Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8511588" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD4/analysis
;
Antigens, CD8/*analysis
;
B-Lymphocytes/*immunology
;
Cell Line
;
Cells, Cultured
;
Cytotoxicity, Immunologic
;
Immunophenotyping
;
Interleukin-10/biosynthesis
;
Interleukin-2/pharmacology
;
Interleukin-4/biosynthesis/pharmacology
;
Interleukin-5/biosynthesis
;
Interleukins/*biosynthesis
;
Ionomycin/pharmacology
;
*Lymphocyte Activation
;
Membrane Glycoproteins/genetics
;
Mice
;
Perforin
;
Pore Forming Cytotoxic Proteins
;
T-Lymphocyte Subsets/*immunology
;
T-Lymphocytes, Cytotoxic/immunology
;
Tetradecanoylphorbol Acetate/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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