Publication Date:
1981-08-07
Description:
Removal of the posterior pituitary from anesthetized male rats results in a prompt and significant increase in circulating prolactin that is reversed by the injection of dopamine. Posterior pituitary extracts, which contain high concentrations of endogenous dopamine, inhibit prolactin secretion from isolated anterior pituitary cells. This inhibition is prevented by incubation of the cells with the dopamine receptor antagonist (+)-butaclamol. The data show that posterior pituitary dopamine reaches the anterior pituitary via the short hypophysial portal vessels and participates in the regulation of prolactin secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, L L -- Hoefer, M T -- Ben-Jonathan, N -- HD 14348/HD/NICHD NIH HHS/ -- NS-13234/NS/NINDS NIH HHS/ -- NS-219/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256264" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cells, Cultured
;
Dopamine/pharmacology/*physiology
;
Luteinizing Hormone/secretion
;
Male
;
Pituitary Gland, Posterior/*physiology
;
Prolactin/*secretion
;
Rats
;
Secretory Rate/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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