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  • 1
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    Electron Dynamics in the Core-Excited CS_{2} Molecule Revealed through Resonant Inelastic X-Ray Scattering Spectroscopy (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-22
    Description: Author(s): T. Marchenko, S. Carniato, L. Journel, R. Guillemin, E. Kawerk, M. Žitnik, M. Kavčič, K. Bučar, R. Bohinc, M. Petric, V. Vaz da Cruz, F. Gel’mukhanov, and M. Simon X-ray radiation impinging on molecules has many medical applications. X-ray-induced electron dynamics in carbon disulfide is studied in order to probe nuclear and electronic degrees of freedom. [Phys. Rev. X 5, 031021] Published Thu Aug 20, 2015
    Electronic ISSN: 2160-3308
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    The Genome sequence of the SARS-associated coronavirus (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-05-06
    Description: We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marra, Marco A -- Jones, Steven J M -- Astell, Caroline R -- Holt, Robert A -- Brooks-Wilson, Angela -- Butterfield, Yaron S N -- Khattra, Jaswinder -- Asano, Jennifer K -- Barber, Sarah A -- Chan, Susanna Y -- Cloutier, Alison -- Coughlin, Shaun M -- Freeman, Doug -- Girn, Noreen -- Griffith, Obi L -- Leach, Stephen R -- Mayo, Michael -- McDonald, Helen -- Montgomery, Stephen B -- Pandoh, Pawan K -- Petrescu, Anca S -- Robertson, A Gordon -- Schein, Jacqueline E -- Siddiqui, Asim -- Smailus, Duane E -- Stott, Jeff M -- Yang, George S -- Plummer, Francis -- Andonov, Anton -- Artsob, Harvey -- Bastien, Nathalie -- Bernard, Kathy -- Booth, Timothy F -- Bowness, Donnie -- Czub, Martin -- Drebot, Michael -- Fernando, Lisa -- Flick, Ramon -- Garbutt, Michael -- Gray, Michael -- Grolla, Allen -- Jones, Steven -- Feldmann, Heinz -- Meyers, Adrienne -- Kabani, Amin -- Li, Yan -- Normand, Susan -- Stroher, Ute -- Tipples, Graham A -- Tyler, Shaun -- Vogrig, Robert -- Ward, Diane -- Watson, Brynn -- Brunham, Robert C -- Krajden, Mel -- Petric, Martin -- Skowronski, Danuta M -- Upton, Chris -- Roper, Rachel L -- New York, N.Y. -- Science. 2003 May 30;300(5624):1399-404. Epub 2003 May 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. mmarra@bccgsc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12730501" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; 5' Untranslated Regions ; Animals ; Base Sequence ; Conserved Sequence ; Coronavirus/classification/genetics ; DNA, Complementary ; Frameshifting, Ribosomal ; *Genome, Viral ; Humans ; Membrane Glycoproteins/chemistry/genetics ; Nucleocapsid Proteins/chemistry/genetics ; Open Reading Frames ; Phylogeny ; RNA Replicase/chemistry/genetics ; RNA, Viral/*genetics/isolation & purification ; Regulatory Sequences, Nucleic Acid ; SARS Virus/classification/*genetics/isolation & purification ; Sequence Analysis, DNA ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins/chemistry/genetics ; Viral Matrix Proteins/chemistry/genetics ; Viral Proteins/chemistry/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-23
    Description: Influenza antiviral agents play important roles in modulating disease severity and in controlling pandemics while vaccines are prepared, but the development of resistance to agents like the commonly used neuraminidase inhibitor oseltamivir may limit their future utility. We report here on a new class of specific, mechanism-based anti-influenza drugs that function through the formation of a stabilized covalent intermediate in the influenza neuraminidase enzyme, and we confirm this mode of action with structural and mechanistic studies. These compounds function in cell-based assays and in animal models, with efficacies comparable to that of the neuraminidase inhibitor zanamivir and with broad-spectrum activity against drug-resistant strains in vitro. The similarity of their structure to that of the natural substrate and their mechanism-based design make these attractive antiviral candidates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jin-Hyo -- Resende, Ricardo -- Wennekes, Tom -- Chen, Hong-Ming -- Bance, Nicole -- Buchini, Sabrina -- Watts, Andrew G -- Pilling, Pat -- Streltsov, Victor A -- Petric, Martin -- Liggins, Richard -- Barrett, Susan -- McKimm-Breschkin, Jennifer L -- Niikura, Masahiro -- Withers, Stephen G -- G0600514/Medical Research Council/United Kingdom -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2013 Apr 5;340(6128):71-5. doi: 10.1126/science.1232552. Epub 2013 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23429702" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antiviral Agents/*chemistry/pharmacology ; Crystallography, X-Ray ; Dogs ; Enzyme Inhibitors/*chemistry/pharmacology ; Humans ; Madin Darby Canine Kidney Cells ; Neuraminidase/*antagonists & inhibitors/chemistry ; Orthomyxoviridae/*drug effects/enzymology ; Oseltamivir/chemistry/pharmacology ; Protein Conformation ; Sialic Acids/*chemistry/pharmacology ; Structure-Activity Relationship ; Zanamivir/chemistry/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    The crystal and molecular structure of tetrakis(μ-octanoato-O,O')-bis(pyridine)dicopper(II)
    Amsterdam : Elsevier
    Polyhedron 12 (1993), S. 1973-1976 
    Details
    ISSN: 0277-5387
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0277-5387(00)81468-0
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  • 5
    Electronic Resource
    Electronic Resource
    Changes of supermolecular structure of polymer materials at various processings
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part C, 33 (1989), S. 573-579 
    Details
    ISSN: 1359-0197
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1359-0197(89)90317-2
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  • 6
    Electronic Resource
    Electronic Resource
    Purification and characterization of verocytotoxin 2 (1988)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 51 (1988), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Verocytotoxin 2 (VT2) was purified from Escherichia coli strain E32511 using, as starting material, cells harvested from a Penassay broth culture incubated for 6 h at 37°C in the presence of mitomycin C (0.2 μg/ml). A crude extract of VT2, obtained by polymyxin B treatment of cell pellets, was purified using differential ammonium sulphate precipitation, and sequential column chromatography. The purified toxin was estimated to have a pI of 6.5 by chromatofocusing and a molecular weight of 42 000 by gel filtration; it had a specific activity of 1.39 × 106 CD50 units/mg protein in Vero cells, and resolved as a major band of Mr 35 000 and another band of 〈14 000 which migrated with the buffer front on reducing SDS-polyacrylamide gel electrophoresis. The purified toxin was not neutralized by VT1 antisera and antisera prepared to this toxin in rabbits did not neutralize VT1, but completely neutralized the activity of the homologous toxin. Purified VT2, when administered intravenously, was lethal to rabbits with an LD50 of 30 μg/kg. Rabbits displayed symptoms of overt haemorrhagic caecitis and flaccid paralysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1988.tb02999.x
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  • 7
    Electronic Resource
    Electronic Resource
    Purification and biological properties of Escherichia coli verocytotoxin (1987)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 41 (1987), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A simple method was developed for purifying Escherichia coli H 30 verocytotoxin (VT). The toxin, released from the cells by exposure to polymyxin B, was subjected to differential ammonium sulphate precipitation and sequential chromatography on hydroxylapatite, chromatofocussing, Cibachron blue, and Sephadex G-100 columns. The purified toxin, of 39 kDa by gel filtration and a pI of 6.72, resolved as a band which migrated at 32 kDa and another band, of less than 14 kDa, which migrated with the buffer front on reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The purified preparation was relatively heat-stable, and had a specific activity of 3 × 109 CD50 units/mg protein in Vero cells, and LD50 values of 0.2, 9.0, and 40 μg proteindeadenylylation. Carbon-limited chemostat cultures showed low glutamine synthetase activity levels but the synthesis of the enzyme was derepressed when the cultures became N-limited. kg in rabbits, rats, and mice, respectively. Antiserum to the toxin specifically neutralized H 30 VT, Shiga toxin, and VT activity from some clinical isolates of VT+E. coli, but not that from a porcine oedema disease strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1987.tb02142.x
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  • 8
    Electronic Resource
    Electronic Resource
    Globotriosyl ceramide is specifically recognized by the escherichia coli verocytotoxin 2
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 152 (1988), S. 674-679 
    Details
    ISSN: 0006-291X
    Keywords: [abr] Gb"3 globotriosyl ceramide - galα1-4galβ1-4glc ceramide, Gb"4 -
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)80091-3
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  • 9
    Electronic Resource
    Electronic Resource
    Globotriosyl ceramide is specifically recognized by the escherichia coli verocytotoxin 2
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 152 (1988), S. 674-679 
    Details
    ISSN: 0006-291X
    Keywords: [abr] Gb"3 globotriosyl ceramide - galα1-4galβ1-4glc ceramide, Gb"4 -
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)80091-3
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  • 10
    Electronic Resource
    Electronic Resource
    Practical experience in utilization of electron beam facility in Yugoslavia
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part C, 35 (1990), S. 641-644 
    Details
    ISSN: 1359-0197
    Keywords: Electron beam ; heatshrinkable products ; radiation technology ; wire and cable
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1359-0197(90)90287-R
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