Publication Date:
1991-08-09
Description:
A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-beta-D- ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raju, U -- Koumenis, C -- Nunez-Regueiro, M -- Eskin, A -- MH41979/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):673-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemical and Biophysical Sciences, University of Houston, TX 77204-5934.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1871602" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aplysia
;
Camptothecin/*pharmacology
;
Circadian Rhythm/*radiation effects
;
Dichlororibofuranosylbenzimidazole/*pharmacology
;
Eye/drug effects
;
In Vitro Techniques
;
*Ocular Physiological Phenomena
;
Time Factors
;
Transcription, Genetic/*drug effects
;
Uridine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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