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  • 1
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    The costs of animal research: origins and options (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cork, L C -- Clarkson, T B -- Jacoby, R O -- Gaertner, D J -- Leary, S L -- Linn, J M -- Pakes, S P -- Ringler, D H -- Strandberg, J D -- Swindle, M M -- New York, N.Y. -- Science. 1997 May 2;276(5313):758-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157554" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare ; Animals ; *Animals, Laboratory ; Costs and Cost Analysis ; Financing, Government ; Laboratory Animal Science/*economics/education ; National Institutes of Health (U.S.)/economics ; Research/*economics ; *Research Support as Topic ; United States ; Veterinary Medicine/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine (1997)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: BACKGROUND: When a pressure overload is placed on the left ventricle, some patients develop relatively modest hypertrophy whereas others develop extensive hypertrophy. Likewise, the occurrence of contractile dysfunction also is variable. The cause of this heterogeneity is not well understood. METHODS AND RESULTS: We recently developed a model of gradual proximal aortic constriction in the adult canine that mimicked the heterogeneity of the hypertrophic response seen in humans. We hypothesized that differences in outcome were related to differences present before banding. Fifteen animals were studied initially. Ten developed left ventricular dysfunction (dys group). Five dogs maintained normal function (nl group). At baseline, the nl group had a lower mean systolic wall stress (96 +/- 9 kdyne/cm2; dys group, 156 +/- 7 kdyne/cm2; P 〈 .0002) and greater relative left ventricular mass (left ventricular weight [g]/body wt [kg], 5.1 +/- 0.36; dys group, 3.9 +/- 0.26; P 〈 .02). On the basis of differences in mean systolic wall stress at baseline, we predicted outcome in the next 28 dogs by using a cutoff of 115 kdyne/cm2. Eighteen of 20 dogs with baseline mean systolic stress 〉 115 kdyne/cm2 developed dysfunction whereas 6 of 8 dogs with resting stress 〈 or = 115 kdyne/cm2 maintained normal function. CONCLUSIONS: We conclude that this canine model mimicked the heterogeneous hypertrophic response seen in humans. In the group that eventually developed dysfunction there was less cardiac mass despite 60% higher wall stress at baseline, suggesting a different set point for regulating myocardial growth in the two groups.
    Keywords: Life Sciences (General)
    Type: Circulation (ISSN 0009-7322); 95; 6; 1601-10
    Format: text
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