Publication Date:
2005-03-19
Description:
The mammalian intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of colonic content. The host tolerates this tremendous bacterial load while maintaining the ability to efficiently respond to pathogenic organisms. In this study, we show that the Bacteroides use a mammalian-like pathway to decorate numerous surface capsular polysaccharides and glycoproteins with l-fucose, an abundant surface molecule of intestinal epithelial cells, resulting in the coordinated expression of this surface molecule by host and symbiont. A Bacteroides mutant deficient in the ability to cover its surface with L-fucose is defective in colonizing the mammalian intestine under competitive conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coyne, Michael J -- Reinap, Barbara -- Lee, Martin M -- Comstock, Laurie E -- AI44193/AI/NIAID NIH HHS/ -- AI53694/AI/NIAID NIH HHS/ -- R01 AI044193/AI/NIAID NIH HHS/ -- R01 AI044193-07/AI/NIAID NIH HHS/ -- R01 AI053694/AI/NIAID NIH HHS/ -- R01 AI053694-03/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1778-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774760" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/metabolism
;
Animals
;
Bacterial Capsules/biosynthesis/chemistry/*metabolism
;
Bacterial Proteins/biosynthesis/metabolism
;
Bacteroides fragilis/enzymology/genetics/growth & development/*metabolism
;
Culture Media
;
Feces/microbiology
;
Fucose/*metabolism
;
Gene Deletion
;
Genes, Bacterial
;
Glycoproteins/biosynthesis/*metabolism
;
Guanosine Diphosphate/metabolism
;
Guanosine Triphosphate/metabolism
;
Humans
;
Hydro-Lyases/genetics/metabolism
;
Intestinal Mucosa/metabolism
;
Intestines/*microbiology
;
Mice
;
Molecular Mimicry
;
Molecular Sequence Data
;
Mutation
;
Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism
;
*Symbiosis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink