Publication Date:
1990-11-09
Description:
The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kotwal, G J -- Isaacs, S N -- McKenzie, R -- Frank, M M -- Moss, B -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):827-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2237434" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Chromatography, Gel
;
Complement C4b/*metabolism
;
*Complement Pathway, Classical
;
Hemolytic Plaque Technique
;
Immunoblotting
;
Molecular Sequence Data
;
Restriction Mapping
;
Vaccinia virus/genetics/*immunology
;
Viral Proteins/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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