Publication Date:
2010-10-12
Description:
Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORgammat, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORgammat(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORgammat(+) precursors. The fate of RORgammat(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORgammat(+) T cells, however, RORgammat(+) ILCs develop in the absence of microbiota. Our study indicates that RORgammat(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawa, Shinichiro -- Cherrier, Marie -- Lochner, Matthias -- Satoh-Takayama, Naoko -- Fehling, Hans Jorg -- Langa, Francina -- Di Santo, James P -- Eberl, Gerard -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):665-9. doi: 10.1126/science.1194597. Epub 2010 Sep 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929731" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptive Immunity
;
Adoptive Transfer
;
Animals
;
Bacterial Physiological Phenomena
;
Cell Differentiation
;
Cell Lineage
;
Fetus/cytology/immunology/metabolism
;
Homeostasis
;
Immunity, Mucosal
;
Intestinal Mucosa/*immunology
;
Intestine, Small/embryology/*immunology/microbiology
;
Liver/cytology/embryology/immunology
;
Lymphocyte Subsets/cytology/*immunology/metabolism
;
Lymphocytes/cytology/*immunology/metabolism
;
Lymphoid Progenitor Cells/*cytology
;
Lymphoid Tissue/cytology/immunology
;
Lymphopoiesis
;
Mice
;
Mice, Transgenic
;
Nuclear Receptor Subfamily 1, Group F, Member 3/*metabolism
;
Receptors, CCR6/metabolism
;
Symbiosis
;
T-Lymphocyte Subsets/cytology/immunology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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