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  • 1
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    SIVcpz in wild chimpanzees (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santiago, Mario L -- Rodenburg, Cynthia M -- Kamenya, Shadrack -- Bibollet-Ruche, Frederic -- Gao, Feng -- Bailes, Elizabeth -- Meleth, Sreelatha -- Soong, Seng-Jaw -- Kilby, J Michael -- Moldoveanu, Zina -- Fahey, Babette -- Muller, Martin N -- Ayouba, Ahidjo -- Nerrienet, Eric -- McClure, Harold M -- Heeney, Jonathan L -- Pusey, Anne E -- Collins, D Anthony -- Boesch, Christophe -- Wrangham, Richard W -- Goodall, Jane -- Sharp, Paul M -- Shaw, George M -- Hahn, Beatrice H -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):465.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Alabama at Birmingham, Birmingham, AL 35294-6024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799233" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild/*virology ; Antibodies, Viral/analysis/urine ; Ape Diseases/*epidemiology ; Cote d'Ivoire/epidemiology ; Feces/virology ; HIV-1/genetics ; Immunoblotting ; Male ; Pan troglodytes/immunology/*virology ; Polymerase Chain Reaction ; Prevalence ; RNA, Viral/analysis ; Simian Acquired Immunodeficiency Syndrome/*epidemiology ; Simian Immunodeficiency Virus/genetics/immunology/*isolation & purification ; Tanzania/epidemiology ; Uganda/epidemiology ; Urine/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Chimpanzee reservoirs of pandemic and nonpandemic HIV-1 (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-05-27
    Description: Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442710/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442710/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keele, Brandon F -- Van Heuverswyn, Fran -- Li, Yingying -- Bailes, Elizabeth -- Takehisa, Jun -- Santiago, Mario L -- Bibollet-Ruche, Frederic -- Chen, Yalu -- Wain, Louise V -- Liegeois, Florian -- Loul, Severin -- Ngole, Eitel Mpoudi -- Bienvenue, Yanga -- Delaporte, Eric -- Brookfield, John F Y -- Sharp, Paul M -- Shaw, George M -- Peeters, Martine -- Hahn, Beatrice H -- P30 AI 27767/AI/NIAID NIH HHS/ -- R01 AI058715/AI/NIAID NIH HHS/ -- R01 AI058715-05/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- R01 AI58715/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):523-6. Epub 2006 May 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16728595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis ; Ape Diseases/epidemiology/virology ; Cameroon/epidemiology ; DNA, Mitochondrial/genetics ; *Disease Outbreaks ; *Disease Reservoirs ; Feces/virology ; HIV Antibodies/analysis ; HIV Infections/epidemiology/*virology ; HIV-1/classification/*genetics ; Haplotypes ; Humans ; Molecular Epidemiology ; Molecular Sequence Data ; Pan troglodytes/classification/*virology ; Phylogeny ; Prevalence ; Recombination, Genetic ; Simian Acquired Immunodeficiency Syndrome/epidemiology/*virology ; Simian Immunodeficiency Virus/classification/*genetics/immunology/isolation & ; purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-09-06
    Description: Recovery from Friend virus 3 (Rfv3) is a single autosomal gene encoding a resistance trait that influences retroviral neutralizing antibody responses and viremia. Despite extensive research for 30 years, the molecular identity of Rfv3 has remained elusive. Here, we demonstrate that Rfv3 is encoded by Apobec3. Apobec3 maps to the same chromosome region as Rfv3 and has broad inhibitory activity against retroviruses, including HIV. Not only did genetic inactivation of Apobec3 convert Rfv3-resistant mice to a susceptible phenotype, but Apobec3 was also found to be naturally disabled by aberrant messenger RNA splicing in Rfv3-susceptible strains. The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701658/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701658/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santiago, Mario L -- Montano, Mauricio -- Benitez, Robert -- Messer, Ronald J -- Yonemoto, Wes -- Chesebro, Bruce -- Hasenkrug, Kim J -- Greene, Warner C -- R01 AI065329/AI/NIAID NIH HHS/ -- R01 AI065329-04/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1343-6. doi: 10.1126/science.1161121.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772436" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*biosynthesis/blood/immunology ; Chromosome Mapping ; Cloning, Molecular ; Cytidine Deaminase/*genetics/metabolism ; Friend murine leukemia virus/*immunology/physiology ; Immunity, Innate ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Sequence Data ; Neutralization Tests ; Retroviridae Infections/genetics/*immunology/virology ; Tumor Virus Infections/genetics/*immunology/virology ; Viremia
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-05-12
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    APOBEC3/Rfv3 and antibody somatic hypermutation [Immunology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-05-28
    Description: Somatic hypermutation (SHM) is an integral process in the development of high-affinity antibodies that are important for recovery from viral infections and vaccine-induced protection. Ig SHM occurs predominantly in germinal centers (GC) via the enzymatic activity of activation-induced deaminase (AID). In contrast, the evolutionarily related apolipoprotein B mRNA-editing enzyme, catalytic...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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