Publication Date:
2006-10-28
Description:
The spindle assembly checkpoint guards the fidelity of chromosome segregation. It requires the close cooperation of cell cycle regulatory proteins and cytoskeletal elements to sense spindle integrity. The role of the centrosome, the organizing center of the microtubule cytoskeleton, in the spindle checkpoint is unclear. We found that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex (gamma-TuRC). However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, Hannah -- Fogeron, Marie-Laure -- Lehmann, Verena -- Lehrach, Hans -- Lange, Bodo M H -- New York, N.Y. -- Science. 2006 Oct 27;314(5799):654-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17068266" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Cycle Proteins/metabolism
;
Cell Line
;
Centrosome/physiology
;
Drosophila Proteins/genetics/*metabolism
;
Drosophila melanogaster
;
Homeodomain Proteins/genetics/metabolism
;
Humans
;
Kinetochores/metabolism
;
Microtubule-Associated Proteins/genetics/*metabolism
;
Microtubules/ultrastructure
;
*Mitosis
;
Protein Kinases/metabolism
;
Protein-Serine-Threonine Kinases
;
RNA Interference
;
Spindle Apparatus/*metabolism/ultrastructure
;
Tubulin/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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