Publication Date:
2012-09-29
Description:
Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na(+),K(+)-ATPase (ATPalpha), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPalpha with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770729/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770729/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhen, Ying -- Aardema, Matthew L -- Medina, Edgar M -- Schumer, Molly -- Andolfatto, Peter -- R01 GM083228/GM/NIGMS NIH HHS/ -- R01-GM083228/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1634-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019645" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Biological/*genetics
;
Amino Acid Sequence
;
Amino Acid Substitution
;
Animals
;
Apocynaceae/*metabolism/parasitology
;
Cardenolides/*metabolism
;
*Evolution, Molecular
;
Genetic Pleiotropy
;
Herbivory/*genetics
;
Host-Parasite Interactions/*genetics
;
Insects/enzymology/*genetics/physiology
;
Molecular Sequence Data
;
Organ Specificity
;
Sodium-Potassium-Exchanging ATPase/chemistry/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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