Publication Date:
1979-01-12
Description:
To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orr, W -- Varani, J -- Gondex, M K -- Ward, P A -- Mundy, G R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):176-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569363" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Resorption/*physiopathology
;
Bone and Bones/*physiopathology
;
Carcinoma 256, Walker/*physiopathology
;
Cell Line
;
Cell Movement
;
*Chemotaxis
;
Chemotaxis, Leukocyte
;
Lymphoma/physiopathology
;
Neoplasm Metastasis
;
Neoplasms, Experimental/physiopathology
;
Organ Culture Techniques
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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