Publication Date:
1983-12-09
Description:
Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitnall, M H -- Gainer, H -- Cox, B M -- Molineaux, C J -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1137-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648526" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cytoplasmic Granules/metabolism
;
*Dynorphins
;
Endorphins/*metabolism
;
Peptide Fragments/*metabolism
;
Pituitary Gland, Posterior/*metabolism/ultrastructure
;
Rats
;
Synaptic Vesicles/metabolism
;
Vasopressins/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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