Publication Date:
1999-03-12
Description:
The rupture force of single covalent bonds under an external load was measured with an atomic force microscope (AFM). Single polysaccharide molecules were covalently anchored between a surface and an AFM tip and then stretched until they became detached. By using different surface chemistries for the attachment, it was found that the silicon-carbon bond ruptured at 2.0 +/- 0.3 nanonewtons, whereas the sulfur-gold anchor ruptured at 1.4 +/- 0.3 nanonewtons at force-loading rates of 10 nanonewtons per second. Bond rupture probability calculations that were based on density functional theory corroborate the measured values.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grandbois -- Beyer -- Rief -- Clausen-Schaumann -- Gaub -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1727-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lehrstuhl fur Angewandte Physik, Ludwig-Maximilians-Universitat, Amalienstrasse 54, D-80799 Munchen, Germany. Institut fur Physikalische und Theoretische Chemie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85748 Garching.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10073936" target="_blank"〉PubMed〈/a〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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