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  • 1
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    Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-08-07
    Description: Antigen-specific T cell activation depends on T cell receptor-ligand interaction and costimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (lg) G1 Fc region (CTLA4lg) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4lg therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7+ antigen-presenting cells. In addition, CTLA4lg induced long-term, donor-specific tolerance, which may have applications to human organ transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lenschow, D J -- Zeng, Y -- Thistlethwaite, J R -- Montag, A -- Brady, W -- Gibson, M G -- Linsley, P S -- Bluestone, J A -- AI29531/AI/NIAID NIH HHS/ -- R29 DK40092/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):789-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ben May Institute, University of Chicago, IL 60637.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1323143" target="_blank"〉PubMed〈/a〉
    Keywords: Abatacept ; Animals ; Antibodies, Monoclonal/therapeutic use ; Antigens, CD ; Antigens, Differentiation/immunology/*therapeutic use ; CTLA-4 Antigen ; Diabetes Mellitus, Experimental/*surgery ; Graft Survival/*immunology/physiology ; Humans ; *Immunoconjugates ; Immunoglobulin Fc Fragments ; Immunoglobulin G ; Immunosuppressive Agents/*therapeutic use ; Islets of Langerhans Transplantation/*immunology/physiology ; Mice ; Mice, Inbred Strains ; Phosphates/analysis/*metabolism ; Receptors, Cell Surface/immunology ; Recombinant Fusion Proteins/*therapeutic use ; Time Factors ; Transplantation, Heterologous/*immunology/physiology ; Uranium/analysis/*metabolism ; *Uranium Compounds
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-08-07
    Description: In vitro, when the B7 molecule on the surface of antigen-presenting cells binds to the T cell surface molecules CD28 and CTLA-4, a costimulatory signal for T cell activation is generated. CTLA4Ig is a soluble form of the extracellular domain of CTLA-4 and binds B7 with high avidity. CTLA4Ig treatment in vivo suppressed T cell-dependent antibody responses to sheep erythrocytes or keyhole limpet hemocyanin. Large doses of CTLA4Ig suppressed responses to a second immunization. Thus, costimulation by B7 is important for humoral immune responses in vivo, and interference with costimulation may be useful for treatment of antibody-mediated autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linsley, P S -- Wallace, P M -- Johnson, J -- Gibson, M G -- Greene, J L -- Ledbetter, J A -- Singh, C -- Tepper, M A -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):792-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1496399" target="_blank"〉PubMed〈/a〉
    Keywords: Abatacept ; Animals ; Antibody Formation/*drug effects ; Antigens, CD ; Antigens, Differentiation/*immunology/metabolism ; CHO Cells ; CTLA-4 Antigen ; Cricetinae ; Erythrocytes/immunology ; Hemocyanin/immunology ; Humans ; Immunization ; *Immunoconjugates ; Immunosuppressive Agents/pharmacokinetics/*pharmacology ; Lymphocyte Activation ; Metabolic Clearance Rate ; Mice ; Mice, Inbred BALB C ; Mice, Inbred Strains ; Recombinant Fusion Proteins/pharmacokinetics/pharmacology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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