Publication Date:
2005-01-22
Description:
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wisloff, Ulrik -- Najjar, Sonia M -- Ellingsen, Oyvind -- Haram, Per Magnus -- Swoap, Steven -- Al-Share, Qusai -- Fernstrom, Mats -- Rezaei, Khadijeh -- Lee, Sang Jun -- Koch, Lauren Gerard -- Britton, Steven L -- DK 54254/DK/NIDDK NIH HHS/ -- DK 57497/DK/NIDDK NIH HHS/ -- HL 64270/HL/NHLBI NIH HHS/ -- RR 17718/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662013" target="_blank"〉PubMed〈/a〉
Keywords:
Adipose Tissue
;
Aerobiosis
;
Aging
;
Animals
;
Blood Pressure
;
Body Weight
;
Breeding
;
Cardiovascular Diseases/*etiology/physiopathology
;
Disease Models, Animal
;
Endothelium, Vascular/physiology
;
Exercise
;
*Exercise Tolerance
;
Female
;
Glucose Tolerance Test
;
Humans
;
Hypertension/etiology/physiopathology
;
Insulin/blood
;
Insulin Resistance
;
Lipids/blood
;
Male
;
Metabolic Syndrome X/etiology/physiopathology
;
Mitochondria, Muscle/metabolism/*physiology
;
Muscle, Skeletal/enzymology/metabolism
;
Oxidation-Reduction
;
Oxygen Consumption
;
PPAR gamma/metabolism
;
Physical Conditioning, Animal
;
*Physical Exertion
;
Rats
;
Risk Factors
;
Running
;
Selection, Genetic
;
Trans-Activators/metabolism
;
Ventricular Function, Left
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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