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  • 1
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    Lectins of distinct specificity in Rhodnius prolixus interact selectively with Trypanosoma cruzi (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: Lectins of different activities were found in the crop, midgut, and hemolymph of the insect Rhodnius prolixus. These were not specific for N-acetyl-D-mannosamine, alpha-N-acetyl-D-galactosamine, and alpha- and beta-galactose, respectively. Lectin receptors were detectable in epimastigote but not in trypomastigote forms of Trypanosoma cruzi, a protozoan parasite of the insect and of humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pereira, M E -- Andrade, A F -- Ribeiro, J M -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):597-600.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7006082" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hemagglutinins ; Hemolymph/parasitology ; Insect Vectors/*parasitology ; *Lectins ; Rhodnius/anatomy & histology/*parasitology ; Triatominae/*parasitology ; Trypanosoma cruzi/growth & development/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A developmentally regulated neuraminidase activity in Trypanosoma cruzi (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: The human pathogen Trypanosoma cruzi (Y strain) contains a neuraminidase activity that varies widely in the different developmental stages of the parasite. The specific neuraminidase activity of infective trypomastigotes obtained from tissue culture and from the bloodstream of infected mice is 7 to 15 times higher than that of the acellular culture forms. Amastigotes were devoid of enzyme activity. The enzyme has a pH optimum of 6.0 to 6.5. Live trypanosomes released sialic acid from human erythrocytes and plasma glycoproteins. Several sialyl compounds were hydrolyzed by the parasite, but the best substrate was the protein orosomucoid. Erythrocytes from infected mice with T. cruzi parasitemia were agglutinated by peanut lectin and the hemagglutination titer was correlated with the degree of parasitemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pereira, M E -- IRO1-AI-18102-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1444-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338592" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Kinetics ; Neuraminidase/*metabolism ; Substrate Specificity ; Trypanosoma cruzi/enzymology/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Lectin activation in Giardia lamblia by host protease: a novel host-parasite interaction (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-04
    Description: A lectin in Giardia lamblia was activated by secretions from the human duodenum, the environment where the parasite lives. Incubation of the secretions with trypsin inhibitors prevented the appearance of lectin activity, implicating proteases as the activating agent. Accordingly, lectin activation was also produced by crystalline trypsin and Pronase; other proteases tested were ineffective. When activated, the lectin agglutinated intestinal cells to which the parasite adheres in vivo. The lectin was most specific to mannose-6-phosphate and apparently was bound to the plasma membrane. Activation of a parasite lectin by a host protease represents a novel mechanism of host-parasite interaction and may contribute to the affinity of Giardia lamblia to the infection site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lev, B -- Ward, H -- Keusch, G T -- Pereira, M E -- P-1-P30-AM 39428-01/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3513312" target="_blank"〉PubMed〈/a〉
    Keywords: Agglutination ; Animals ; Duodenum/enzymology/parasitology ; Giardia/*metabolism ; *Host-Parasite Interactions ; Humans ; Intestine, Small/enzymology/*parasitology ; Lectins/*metabolism ; Mice ; Peptide Hydrolases/*metabolism ; Sheep ; Species Specificity ; Trypsin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-12-04
    Description: A specific inhibitor of the neuraminidase of the protozoan parasite Trypanosoma cruzi was isolated recently and named cruzin. It is now shown that cruzin is similar to high-density lipoprotein by amino acid homology, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, by immunoblot analysis, and by isoelectric focusing. Cruzin purified by ion exchange chromatography and high-density lipoprotein isolated by density gradient ultracentrifugation inhibited Trypanosoma cruzi neuraminidase to the same extent. Cruzin or high-density lipoprotein restores to normal the decreased multiplication rate of Trypanosoma cruzi epimastigotes grown in a medium depleted of lipoproteins, suggesting that it may be important for survival of the parasite in nature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prioli, R P -- Ordovas, J M -- Rosenberg, I -- Schaefer, E J -- Pereira, M E -- AI 07380/AI/NIAID NIH HHS/ -- AI 18102/AI/NIAID NIH HHS/ -- HL 35243/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1987 Dec 4;238(4832):1417-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Inc., Boston, MA 02111.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3120314" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Anti-Infective Agents ; Apolipoprotein A-I ; Apolipoproteins A/genetics/immunology ; Blood Proteins/immunology/pharmacology/*physiology ; Isoelectric Focusing ; Lipoproteins, HDL/*physiology ; Neuraminidase/antagonists & inhibitors ; Trypanosoma cruzi/*enzymology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Structural and Functional Properties of Trypanosoma Trans-Sialidase (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 48 (1994), S. 499-523 
    Details
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
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  • 6
    Electronic Resource
    Electronic Resource
    Identification of developmentally regulated Giardia lamblia cyst antigens using GCSA-1, a cyst-specific monoclonal antibody (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: GCSA-1, a monoclonal antibody raised against cysts generated in vitro was shown to be Giardia cyst-specific by immunoblot analysis and immunofluorescence. GCSA-1 recognized four polypeptides ranging from 29–45kD present in the cyst wall. These antigens appeared within eight hours of exposure of trophozoites to encystation medium and were shown to be synthesized by encysting parasites by means of metabolic labelling with [35S]-cysteine. Trophozoites were not stained by the antibody. GCSA-1 also reacted with in vivo cysts obtained from faeces of infected humans, gerbils and mice. These data demonstrate that the determinants recognized by GCSA-1 are early cyst antigens which are developmentally regulated and conserved components of the cyst wall. The actual role of the antigens detected by GCSA-1 in encystation are unknown, but they represent a potential target for strategies directed at inhibiting this process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00570.x
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  • 7
    Electronic Resource
    Electronic Resource
    δ-Aminolevulinic Acid Dehydratase Activity in Weanling and Adult Rats Exposed to Lead Acetate (1996)
    Springer
    Bulletin of environmental contamination and toxicology 57 (1996), S. 47 -53 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900154
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  • 8
    Electronic Resource
    Electronic Resource
    Methyl Mercury Exposure During Post-Natal Brain Growth Alters Behavioral Response to SCH 23390 in Young Rats (1999)
    Springer
    Bulletin of environmental contamination and toxicology 63 (1999), S. 256-262 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289900974
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  • 9
    Electronic Resource
    Electronic Resource
    Mercury desorption from contaminated sediments (1991)
    Springer
    Water, air & soil pollution 56 (1991), S. 77-82 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The effects of pH and ionic strength on the release of Hg from contaminated coastal sediments to water were evaluated in a series of laboratory experiments. Data show that the higher the ionic strength and the pH the smaller is the amount of Hg desorbed into solutions. The effect of the ionic strength on the leaching of Hg from contaminated sediments is more evident for values lower than 0.4 mol dm−3, while the influence of pH becomes more pronounced for values lower than 7. Based on qualitative concepts from colloid chemistry an attempt is made to provide an explanation of the observed results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342262
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  • 10
    Electronic Resource
    Electronic Resource
    Episodic targeting aggression and the histories of Lemur social groups (1989)
    Springer
    Behavioral ecology and sociobiology 25 (1989), S. 3-12 
    Details
    ISSN: 1432-0762
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Periodically, members of captive Lemur social groups target others for intense aggression. Over periods of several days, weeks, and sometimes months, one to three lemurs persistently follow and attack one or two particular group mates until the targets no longer associate with their group. Episodic targeting aggression is nonrandom with regard to time of year, group size and sex ratio, and the kinship, age, and gender of targets. The vast majority of episodes observed over the past 18 years at the Duke University Primate Center (DUPC) has occurred between like-sex adolescents and adults in conjunction with estrous cycling or infant births and most often after groups have reached apparent critical sizes. When unrelated adults have shared group membership, members of one family have almost invariably first targeted members of the other. In several groups, entire matrilines have gradually been evicted by members of another across periods of several years. When non-relatives have been absent, lemurs have evicted relatives that had previously formed separate subgroups. Episodic targeting aggression has been documented at the DUPC in over a dozen different social groups, comprising three different species. The phenomenon occurs repeatedly in groups held in a variety of large outdoor runs as well as in outdoor enclosures providing naturalistic space and physical structure. More-over, an appreciable number of recent observations in Madagascar suggest that the patterns we have documented well represent the phenomenon as it occurs in the wild. Targeting aggression based on group size, sex ratio, kinship and gender has been reported for no other primate taxon. We suggest that episodic targeting aggression reflects heretofore undescribed tactics in reproductive competition that may characterize many lemurid and indriid taxa. As such, the phenomenon has broad implications for the structure of lemur social groups and populations. Provisional models of the social dynamics and histories of Lemur social groups are presented for evaluation during upcoming field work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299705
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